α7 nicotinic acetylcholine receptor agonist attenuates allergen-induced immediate nasal response in murine model of allergic rhinitis

• Published in: Journal of Veterinary Medical Science Vol. 86; no. 7; pp. 824 - 827
• Main Authors: OGATA, Sawako, MIURA, Kento, MATSUURA, Anna, HOSOMI, Naohisa, MORI, Akio, YAMASHITA, Shuhei, YAMASAKI, Norimasa, KITAMURA, Noriko, UDA, Naoto, GOTOH, Minoru, NAKAJIMA, Shotaro, KAMINUMA, Osamu
• Format: Journal Article
• Language: English
• Published: Japan JAPANESE SOCIETY OF VETERINARY SCIENCE 2024; Japan Science and Technology Agency; The Japanese Society of Veterinary Science
• Subjects: Acetylcholine receptors (nicotinic); Agonists; Allergens; Allergic rhinitis; Allergies; alpha7 Nicotinic Acetylcholine Receptor - agonists; Anaphylaxis; Animal models; Animals; Benzylidene Compounds - pharmacology; Benzylidene Compounds - therapeutic use; Disease Models, Animal; Female; Leukocytes (eosinophilic); Lymphocytes T; Mast cells; Mice; Mice, Inbred BALB C; murine model; Nicotinic Agonists - pharmacology; Nicotinic Agonists - therapeutic use; Ovalbumin; Passive cutaneous anaphylaxis; Pharmacology; Pyridines - pharmacology; Pyridines - therapeutic use; Rhinitis, Allergic - drug therapy; α7 nicotinic acetylcholine receptor; allergic rhinitis; murine model; α7 nicotinic acetylcholine receptor
• ISSN: 0916-7250; 1347-7439; 1347-7439
• DOI: 10.1292/jvms.24-0033

The expression of nicotinic acetylcholine receptor (nAChR) subunits on various immune cells suggests their involvement in allergic rhinitis. However, how exactly they contribute to this pathogenesis is not yet confirmed. Our present study examined the therapeutic potential of GTS-21, an α7 nAChR agonist, for treating allergic rhinitis by employing its mouse models. GTS-21 treatment reduced allergen-induced immediate nasal response in ovalbumin (OVA)-sensitized model. However, nasal hyperresponsiveness or eosinophil infiltration elicited in either the OVA-sensitized or T helper 2 cell-transplanted model was not affected by GTS-21. GTS-21 did not alter allergen-induced passive cutaneous anaphylaxis response in anti-dinitrophenyl IgE-sensitized mice. This evidence implies GTS-21’s potential to alleviate allergic rhinitis without perturbing T cells or mast cells.