Humoral response to the central unglycosylated region of the respiratory syncytial virus attachment protein
To characterize the humoral response to the unglycosylated central region of the respiratory syncytial virus (RSV) attachment (G) protein, we generated glutathione S-transferase (GST)–RSV G subdomains (central core (CC), residues 151–190; proximal central core (PCC), 151–172; and distal central core...
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| Published in | Vaccine Vol. 28; no. 38; pp. 6242 - 6246 |
|---|---|
| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Kidlington
Elsevier Ltd
31.08.2010
Elsevier Elsevier Limited |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0264-410X 1873-2518 1873-2518 |
| DOI | 10.1016/j.vaccine.2010.07.011 |
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| Abstract | To characterize the humoral response to the unglycosylated central region of the respiratory syncytial virus (RSV) attachment (G) protein, we generated glutathione S-transferase (GST)–RSV G subdomains (central core (CC), residues 151–190; proximal central core (PCC), 151–172; and distal central core (DCC), 173–190) to screen paired sera from RSV subtype A- or B-infected adults in hospitalized or outpatient settings. Following RSV infection, a ≥4-fold increase in homo- and heterosubtypic IgG response was noted in most subjects against the RSV G CC and PCC regions; in contrast, such titer increases against the RSV G DCC was only noted in a homosubtypic manner. Our results have implications for RSV G-based serological diagnostics and vaccine development. |
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| AbstractList | To characterize the humoral response to the unglycosylated central region of the respiratory syncytial virus (RSV) attachment (G) protein, we generated glutathione S-transferase (GST)-RSV G subdomains (central core (CC), residues 151-190; proximal central core (PCC), 151-172; and distal central core (DCC), 173-190) to screen paired sera from RSV subtype A- or B-infected adults in hospitalized or outpatient settings. Following RSV infection, a >or=4-fold increase in homo- and heterosubtypic IgG response was noted in most subjects against the RSV G CC and PCC regions; in contrast, such titer increases against the RSV G DCC was only noted in a homosubtypic manner. Our results have implications for RSV G-based serological diagnostics and vaccine development. To characterize the humoral response to the unglycosylated central region of the respiratory syncytial virus (RSV) attachment (G) protein, we generated glutathione S-transferase (GST)-RSV G subdomains (central core (CC), residues 151–190; proximal central core (PCC), 151–172, and distal central core (DCC), 173–190) to screen paired sera from RSV subtype A- or B-infected adults in hospitalized or outpatient settings. Following RSV infection, a ≥ 4-fold increase in homo- and heterosubtypic IgG response was noted in most subjects against the RSV G CC and PCC regions; in contrast, such titer increases against the RSV G DCC was only noted in a homosubtypic manner. Our results have implications for RSV G-based serological diagnostics and vaccine development. To characterize the humoral response to the unglycosylated central region of the respiratory syncytial virus (RSV) attachment (G) protein, we generated glutathione S-transferase (GST)-RSV G subdomains (central core (CC), residues 151-190; proximal central core (PCC), 151-172; and distal central core (DCC), 173-190) to screen paired sera from RSV subtype A- or B-infected adults in hospitalized or outpatient settings. Following RSV infection, a ≥4-fold increase in homo- and heterosubtypic IgG response was noted in most subjects against the RSV G CC and PCC regions; in contrast, such titer increases against the RSV G DCC was only noted in a homosubtypic manner. Our results have implications for RSV G-based serological diagnostics and vaccine development. To characterize the humoral response to the unglycosylated central region of the respiratory syncytial virus (RSV) attachment (G) protein, we generated glutathione S-transferase (GST)-RSV G subdomains (central core (CC), residues 151-190; proximal central core (PCC), 151-172; and distal central core (DCC), 173-190) to screen paired sera from RSV subtype A- or B-infected adults in hospitalized or outpatient settings. Following RSV infection, a >or=4-fold increase in homo- and heterosubtypic IgG response was noted in most subjects against the RSV G CC and PCC regions; in contrast, such titer increases against the RSV G DCC was only noted in a homosubtypic manner. Our results have implications for RSV G-based serological diagnostics and vaccine development.To characterize the humoral response to the unglycosylated central region of the respiratory syncytial virus (RSV) attachment (G) protein, we generated glutathione S-transferase (GST)-RSV G subdomains (central core (CC), residues 151-190; proximal central core (PCC), 151-172; and distal central core (DCC), 173-190) to screen paired sera from RSV subtype A- or B-infected adults in hospitalized or outpatient settings. Following RSV infection, a >or=4-fold increase in homo- and heterosubtypic IgG response was noted in most subjects against the RSV G CC and PCC regions; in contrast, such titer increases against the RSV G DCC was only noted in a homosubtypic manner. Our results have implications for RSV G-based serological diagnostics and vaccine development. To characterize the humoral response to the unglycosylated central region of the respiratory syncytial virus (RSV) attachment (G) protein, we generated glutathione S-transferase (GST)-RSV G subdomains (central core (CC), residues 151-190; proximal central core (PCC), 151-172; and distal central core (DCC), 173-190) to screen paired sera from RSV subtype A- or B-infected adults in hospitalized or outpatient settings. Following RSV infection, a >=4-fold increase in homo- and heterosubtypic IgG response was noted in most subjects against the RSV G CC and PCC regions; in contrast, such titer increases against the RSV G DCC was only noted in a homosubtypic manner. Our results have implications for RSV G-based serological diagnostics and vaccine development. Abstract To characterize the humoral response to the unglycosylated central region of the respiratory syncytial virus (RSV) attachment (G) protein, we generated glutathione S-transferase (GST)–RSV G subdomains (central core (CC), residues 151–190; proximal central core (PCC), 151–172; and distal central core (DCC), 173–190) to screen paired sera from RSV subtype A- or B-infected adults in hospitalized or outpatient settings. Following RSV infection, a ≥4-fold increase in homo- and heterosubtypic IgG response was noted in most subjects against the RSV G CC and PCC regions; in contrast, such titer increases against the RSV G DCC was only noted in a homosubtypic manner. Our results have implications for RSV G-based serological diagnostics and vaccine development. |
| Author | Walsh, Edward E. Biear, Jamie N. Lightfoote, Paula M. Falsey, Ann R. Murata, Yoshihiko |
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| CitedBy_id | crossref_primary_10_1146_annurev_immunol_051116_052206 crossref_primary_10_3389_fmicb_2017_02301 crossref_primary_10_2478_arsm_2023_0011 crossref_primary_10_1371_journal_ppat_1008942 crossref_primary_10_1016_j_pep_2016_12_003 crossref_primary_10_1016_j_vaccine_2011_07_114 crossref_primary_10_1371_journal_pone_0175384 crossref_primary_10_1016_j_jviromet_2023_114712 crossref_primary_10_1371_journal_pone_0153019 crossref_primary_10_1002_jmv_23881 crossref_primary_10_1586_17476348_2013_814409 crossref_primary_10_1089_vim_2011_0094 crossref_primary_10_1016_j_vaccine_2014_06_024 crossref_primary_10_1371_journal_pone_0034331 crossref_primary_10_1016_j_vaccine_2012_06_016 crossref_primary_10_1371_journal_pone_0094269 |
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| Keywords | Attachment protein Respiratory syncytial virus Humoral response Humoral immunity Protein |
| Language | English |
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| Snippet | To characterize the humoral response to the unglycosylated central region of the respiratory syncytial virus (RSV) attachment (G) protein, we generated... Abstract To characterize the humoral response to the unglycosylated central region of the respiratory syncytial virus (RSV) attachment (G) protein, we... |
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| SubjectTerms | Age Aged Aged, 80 and over Allergy and Immunology Antibodies, Viral - immunology Applied microbiology Attachment protein Biological and medical sciences Chronic obstructive pulmonary disease Derivatives Enzyme-Linked Immunosorbent Assay Fundamental and applied biological sciences. Psychology Glutathione transferase Heart attacks Hep G2 Cells Hospitalization Humans Humoral response Immunity, Humoral Immunoglobulin G - immunology Microbiology Middle Aged Plasmids Polymerase chain reaction Proteins Respiratory syncytial virus Respiratory Syncytial Virus Infections - immunology Respiratory Syncytial Virus Infections - prevention & control Respiratory Syncytial Virus Vaccines - immunology Respiratory Syncytial Virus, Human - immunology Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) Viral Envelope Proteins - immunology |
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| Title | Humoral response to the central unglycosylated region of the respiratory syncytial virus attachment protein |
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