Seroepidemiology of Reovirus in Healthy Dogs in Six Prefectures in Japan

• Published in: Journal of Veterinary Medical Science Vol. 76; no. 3; pp. 471 - 475
• Main Authors: HWANG, Chung Chew, MOCHIZUKI, Masami, MAEDA, Ken, OKUDA, Masaru, MIZUNO, Takuya
• Format: Journal Article
• Language: English
• Published: Japan JAPANESE SOCIETY OF VETERINARY SCIENCE 2014; Japan Science and Technology Agency; The Japanese Society of Veterinary Science
• Subjects: Age Factors; Animals; Antibodies, Neutralizing - blood; canine; Clinical Patholog; Dog Diseases - epidemiology; Dog Diseases - virology; Dogs; Japan - epidemiology; Neutralization Tests - veterinary; neutralizing antibody; plaque reduction neutralization test; Reoviridae Infections - epidemiology; Reoviridae Infections - veterinary; reovirus; Seroepidemiologic Studies; seroepidemiology; Japan
• ISSN: 0916-7250; 1347-7439; 1347-7439
• DOI: 10.1292/jvms.13-0472

Reovirus infection is common in mammals. However, seroepidemiological data of reovirus neutralizing antibodies are limited in dogs. In this study, sera of 65 healthy dogs from six prefectures across Japan were tested for neutralizing antibodies against reovirus serotype 1 strain Lang (T1L), serotype 2 strain Amy (T2A) and serotype 3 strain Dearing (T3D) using plaque reduction neutralization test (PRNT). Seropositivity against reovirus T1L, T2A and T3D was 53.85%, 33.85% and 46.15%, respectively. Distribution of reovirus seropositive samples displayed no distinguishable geographical pattern. However, reovirus seropositivity increased with age and in dogs housed outdoor. Co-infection of multiple reovirus serotypes in dogs was also detected. These data will provide valuable insights towards the usage of reovirus in oncolytic virotherapy in canine cancers.