Noninvasive molecular imaging of small living subjects using Raman spectroscopy

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 105; no. 15; pp. 5844 - 5849
• Main Authors: Keren, S, Zavaleta, C, Cheng, Z, de la Zerda, A, Gheysens, O, Gambhir, S.S
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 15.04.2008; National Acad Sciences
• Subjects: Animal models; Animals; Biological Sciences; Bioluminescence; carbon nanotubes; Diagnostic Imaging - methods; Fluorescence; image analysis; Imaging; Liver; Liver - cytology; Liver - metabolism; Liver - pathology; Medical imaging; Mice; Molecular imaging; Molecules; Multiplexing; Nanoparticles; Nanoparticles - administration & dosage; Nanotechnology; Nanotubes; Phantoms, Imaging; Pharmacokinetics; Raman scattering; Raman spectroscopy; Spectroscopy; Spectrum analysis; Spectrum Analysis, Raman - methods; Tumors

Molecular imaging of living subjects continues to rapidly evolve with bioluminescence and fluorescence strategies, in particular being frequently used for small-animal models. This article presents noninvasive deep-tissue molecular images in a living subject with the use of Raman spectroscopy. We de...