N-trans-Feruloyltyramine as a Melanin Biosynthesis Inhibitor

• Published in: Biological & Pharmaceutical Bulletin Vol. 30; no. 10; pp. 1972 - 1974
• Main Authors: Efdi, Mai, Ohguchi, Kenji, Akao, Yukihiro, Nozawa, Yoshinori, Koketsu, Mamoru, Ishihara, Hideharu
• Format: Journal Article
• Language: English
• Published: Japan The Pharmaceutical Society of Japan 01.10.2007; Pharmaceutical Society of Japan; Japan Science and Technology Agency
• Subjects: Animals; Annonaceae - chemistry; Blotting, Western; Cell Line, Tumor; Chromatography, High Pressure Liquid; Coumaric Acids - isolation & purification; Coumaric Acids - pharmacology; Magnetic Resonance Spectroscopy; Mass Spectrometry; melanin; Melanins - antagonists & inhibitors; Melanins - biosynthesis; melanogenesis; Melanoma, Experimental - drug therapy; Melanoma, Experimental - enzymology; Melanoma, Experimental - pathology; Mice; Monophenol Monooxygenase - metabolism; Plant Extracts - chemistry; Signal Transduction - drug effects; Spectrophotometry, Infrared; Tyramine - analogs & derivatives; Tyramine - isolation & purification; Tyramine - pharmacology; tyrosinase
• ISSN: 0918-6158; 1347-5215
• DOI: 10.1248/bpb.30.1972

In this study, we examined the effect of N-trans-feruloyltyramine (FA) on melanogenesis in mouse B16 melanoma cells. Melanogenesis was inhibited by FA in a dose-dependent manner. FA exhibited a greater potency than kojic acid as a standard inhibitor of melanogenesis. Moreover, treatment of B16 melanoma cells with FA was found to cause marked decreases in the expression levels of tyrosinase. FA-induced downregulation of tyrosinase resulted in suppression of melanin biosynthesis in murine B16 melanoma cells.