Effectiveness of Povidone-Iodine 1% Eye Drop on Streptococcus pneumoniae and Escherichia coli Induced-Keratitis in Mice
Bacterial keratitis is an ophthalmic infection that may result in irreversible corneal damage. This study aimed to examine the effectiveness of povidone-iodine eye drop 1% in eye infection caused by inoculation of and of mice. In this study, 49 adult male CBA/J mice were used that divided into seven...
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Published in | Galen Vol. 8; p. e1161 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
Iran
02.06.2019
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Subjects | |
Online Access | Get full text |
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Summary: | Bacterial keratitis is an ophthalmic infection that may result in irreversible corneal damage. This study aimed to examine the effectiveness of povidone-iodine eye drop 1% in eye infection caused by inoculation of
and
of mice.
In this study, 49 adult male CBA/J mice were used that divided into seven equal groups. The corneas of all mice were scratched and infected with a clinical strain of either
or
topically, except control group. Subgroups received chloramphenicol 0.5% eye drop twice daily in case of
infection or ciprofloxacin 0.3% eye drop every 4 hours following
infection from or povidone-iodine 1% eye drop in both groups, from post infection (PI) day 3 to7. Slit lamp examinations (SLE) of the corneas and eyes were performed every day to examine detectable or intense corneal opacity and erosion.
In all infected mice, SLE scores were significantly higher than the control group on PI day 3. Scores increased steadily by time in all infected groups without treatment, reached to maximal value on PI day 7. In infected groups, treatment with either povidone-iodine 1% or chloramphenicol 0.5% or ciprofloxacin 0.3% on day 3, significantly decreased the SLE scores on PI day 7.
Povidone-Iodine 1% was effective to decrease
and
induced-keratitis symptoms in mice. Treatment with povidone-iodine 1% was observed time-dependently and was comparable to common eye drop antibiotics. |
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ISSN: | 2588-2767 2322-2379 |
DOI: | 10.31661/gmj.v8i.1161 |