中药提取物对鸡大肠杆菌病预防性干预及其机理研究

以四种中药提取物（连翘酯苷提取物、苦参提取物、苍术提取物以及硫酸小檗碱）饱和水溶液混合物对鸡大肠杆菌发病模型预防性干预,检测鸡大肠杆菌病模型标志性炎症因子m RNA表达水平。结果表明,四种中药提取物饱和水溶液混合物对鸡大肠杆菌病发病过程具有较明显预防性干预作用（P〈0.05）;鸡大肠杆菌病发病模型中NF-κb、TNF-αm RNA表达水平经中药提取物饱和水溶液混合物干预后均明显低于阳性对照组（P〈0.05）,但仍高于空白对照组（P〈0.05）;IL-10 m RNA表达水平在中药提取物混合水溶液作用下较阳性对照组升高（P〈0.05）。四种中药提取物饱和水溶液可能通过干预感染鸡炎症进程预防鸡大肠...

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Bibliographic Details
Published in东北农业大学学报 Vol. 47; no. 5; pp. 54 - 61
Main Author 张瀚元 张秀英 施路一
Format Journal Article
LanguageChinese
Published 东北农业大学动物医学学院,哈尔滨,150030%黑龙江省野生动物研究所,哈尔滨,150081 2016
Subjects
中药
大肠杆菌病
抑菌作用
抗炎
抑菌作用
traditional Chinese medicine (TCM)
bacterio-static action
anti-inflammatory
中药
大肠杆菌病
抗炎
E. colibacillosis
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Summary:以四种中药提取物（连翘酯苷提取物、苦参提取物、苍术提取物以及硫酸小檗碱）饱和水溶液混合物对鸡大肠杆菌发病模型预防性干预,检测鸡大肠杆菌病模型标志性炎症因子m RNA表达水平。结果表明,四种中药提取物饱和水溶液混合物对鸡大肠杆菌病发病过程具有较明显预防性干预作用（P〈0.05）;鸡大肠杆菌病发病模型中NF-κb、TNF-αm RNA表达水平经中药提取物饱和水溶液混合物干预后均明显低于阳性对照组（P〈0.05）,但仍高于空白对照组（P〈0.05）;IL-10 m RNA表达水平在中药提取物混合水溶液作用下较阳性对照组升高（P〈0.05）。四种中药提取物饱和水溶液可能通过干预感染鸡炎症进程预防鸡大肠杆菌病。
Bibliography:23-1391/S
ZHANG Hanyuan, ZHANG Xiuying, SHI Luyi （1. School of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, China; 2. Wildlife Research Institute of Heilongjiang Province, Harbin 150081, China）
This experiment intervented the establishment of the model of the avian colibacillosis preventively by the mixture of saturated aqueous solution of the four kinds of traditional Chinese medicine extracts above as well as detecting the level of expression of inflammatory factor m RNA.There were obvious preventive intervention on the process of the avian colibacillosis in the mixture of saturated aqueous solution of the four kinds of traditional Chinese medicine extracts（P〈0.05）;The expression level of the NF-κb and TNF-α m RNA of the intervention group was significantly lower than that of the positive control group in the model of the avian colibacillosis（P〈0.05）, but it was higher than the blank control group（P〈0.05）; Compared with the positive control group, the expression levels of the IL-10 m
ISSN:1005-9369