替莫唑胺在垂体腺瘤治疗中的应用及进展

垂体腺瘤是临床常见的原发性中枢神经系统肿瘤,其中侵袭性腺瘤和垂体腺癌因其侵袭性生长的病理生理学特点仍是目前神经外科治疗之难点,需手术切除病灶辅助放射治疗和药物化疗。近年来,由于替莫唑胺对功能性垂体腺瘤、侵袭性垂体腺瘤和垂体腺癌的治疗取得进展,使其颇受临床关注,尤其是O6-甲基鸟嘌呤-DNA甲基转移酶可否作为判断替莫唑胺疗效的指标,成为烷化剂化疗药物之研究热点。...

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Bibliographic Details
Published in中国现代神经疾病杂志 Vol. 15; no. 12; pp. 1001 - 1004
Main Author 林益光 刘晓民
Format Journal Article
LanguageChinese
Published 300211,天津医科大学第二医院神经外科 2015
Subjects
O（6）-甲基鸟嘌呤DNA甲基转移酶
垂体肿瘤
替莫唑胺（非MeSH词）
综述
Pituitary neoplasms
替莫唑胺(非MeSH词)
Temozolomide (not in MeSH)
垂体肿瘤
综述
Review
O -methylguanine-DNA methyltransferase
O-甲基鸟嘌呤DNA甲基转移酶
Online AccessGet full text
ISSN1672-6731
DOI10.3969/j.issn.1672-6731.2015.12.017

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Summary:垂体腺瘤是临床常见的原发性中枢神经系统肿瘤,其中侵袭性腺瘤和垂体腺癌因其侵袭性生长的病理生理学特点仍是目前神经外科治疗之难点,需手术切除病灶辅助放射治疗和药物化疗。近年来,由于替莫唑胺对功能性垂体腺瘤、侵袭性垂体腺瘤和垂体腺癌的治疗取得进展,使其颇受临床关注,尤其是O6-甲基鸟嘌呤-DNA甲基转移酶可否作为判断替莫唑胺疗效的指标,成为烷化剂化疗药物之研究热点。
Bibliography:Pituitary neoplasms; Temozolomide（not in Me SH）; O（6）-methylguanine-DNAmethyltransferase; Review
LIN Yi-guang, LIU Xiao-min （ Department of Neurosurgery, the Second Hospital of Tianjin Medical University, Tianjin 300211, China）
Pituitary adenoma is a common primary tumor in central nervons system. The aggressivepituitary adenomas show invasive characteristics with higher recurrence rate and worse prognosis, whichnormally need the comprehensive therapy of surgery, radiotherapy and chemical medications. The therapyof aggressive pituitary adenomas by temozolomide and whether O6-methylguanine-DNA methyltransferase（MGMT） could predict the curative effect of temozolomide have become hot spots in recent years. Thisreview intends to illustrate the advance of the therapy of aggressive pituitary adenomas by temozolomide.
12-1363/R
ISSN:1672-6731
DOI:10.3969/j.issn.1672-6731.2015.12.017