心脏死亡后捐献角膜用作穿透性角膜移植术供体的安全性研究
目的：探讨心脏死亡后捐献（donation after cardiac death,DCD）角膜供体行穿透性角膜移植的安全性。方法：按照时间先后顺序,采用DCD供体角膜行穿透性角膜移植术,术后3~4mo检测角膜植片内皮细胞密度及最佳矫正视力。结果：共统计14例26眼DCD角膜供体纳入本研究。供体年龄0.5~61（平均38.3±15.6）岁;死亡原因包括脑外伤9例,心肌梗塞2例,脑干出血2例,呼吸循环衰竭1例。14例DCD捐献者28眼,因2眼暴露性角膜炎用作科学研究,共26眼用于穿透性角膜移植。所有患者手术过程顺利,手术后3~4mo未发生排斥反应,角膜植片保持透明。手术后3~4mo角膜内皮细胞密...
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| Published in | 国际眼科杂志 Vol. 15; no. 2; pp. 317 - 319 |
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| Main Author | |
| Format | Journal Article |
| Language | Chinese |
| Published |
华中科技大学同济医学院附属同济医院 手术室, 中国湖北省武汉市,430030%华中科技大学同济医学院附属同济医院 眼科, 中国湖北省武汉市,430030%华中科技大学同济医学院附属同济医院 器官移植科, 中国湖北省武汉市,430030
2015
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| Abstract | 目的：探讨心脏死亡后捐献（donation after cardiac death,DCD）角膜供体行穿透性角膜移植的安全性。方法：按照时间先后顺序,采用DCD供体角膜行穿透性角膜移植术,术后3~4mo检测角膜植片内皮细胞密度及最佳矫正视力。结果：共统计14例26眼DCD角膜供体纳入本研究。供体年龄0.5~61（平均38.3±15.6）岁;死亡原因包括脑外伤9例,心肌梗塞2例,脑干出血2例,呼吸循环衰竭1例。14例DCD捐献者28眼,因2眼暴露性角膜炎用作科学研究,共26眼用于穿透性角膜移植。所有患者手术过程顺利,手术后3~4mo未发生排斥反应,角膜植片保持透明。手术后3~4mo角膜内皮细胞密度794~4 347（平均2 305±827）个/mm2,其中低于1 000个/mm2者1例（3.8%）,1 000~2 000个/mm2者9例（34.6%）,大于2 000个/mm2者16例（61.5%）。26例角膜移植受者年龄20~80（平均40.7±17.1）岁。手术前最佳矫正视力为光感（＋）~0.08（平均0.027±0.024）;手术后3~4mo最佳矫正视力为0.2~0.8（平均0.52±0.182）,两者比较差异有显著统计学意义（t=3.96,P〈0.01）。结论：DCD捐献角膜用作穿透性角膜移植供体具有较高的安全性。 |
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| AbstractList | 目的：：探讨心脏死亡后捐献( donation after cardiac death, DCD)角膜供体行穿透性角膜移植的安全性。方法：按照时间先后顺序,采用DCD供体角膜行穿透性角膜移植术,术后3~4 mo检测角膜植片内皮细胞密度及最佳矫正视力。结果：共统计14例26眼DCD角膜供体纳入本研究。供体年龄0.5~61(平均38.3±15.6)岁；死亡原因包括脑外伤9例,心肌梗塞2例,脑干出血2例,呼吸循环衰竭1例。14例DCD捐献者28眼,因2眼暴露性角膜炎用作科学研究,共26眼用于穿透性角膜移植。所有患者手术过程顺利,手术后3~4 mo未发生排斥反应,角膜植片保持透明。手术后3~4 mo角膜内皮细胞密度794~4347(平均2305±827)个/mm2,其中低于1000个/mm2者1例(3.8%),1000~2000个/mm2者9例(34.6%),大于2000个/mm2者16例(61.5%)。26例角膜移植受者年龄20~80(平均40.7±17.1)岁。手术前最佳矫正视力为光感(+)~0.08(平均0.027±0.024)；手术后3~4mo最佳矫正视力为0.2~0.8(平均0.52±0.182),两者比较差异有显著统计学意义(t=3.96,P<0.01)。结论：DCD捐献角膜用作穿透性角膜移植供体具有较高的安全性。 目的：探讨心脏死亡后捐献（donation after cardiac death,DCD）角膜供体行穿透性角膜移植的安全性。方法：按照时间先后顺序,采用DCD供体角膜行穿透性角膜移植术,术后3~4mo检测角膜植片内皮细胞密度及最佳矫正视力。结果：共统计14例26眼DCD角膜供体纳入本研究。供体年龄0.5~61（平均38.3±15.6）岁;死亡原因包括脑外伤9例,心肌梗塞2例,脑干出血2例,呼吸循环衰竭1例。14例DCD捐献者28眼,因2眼暴露性角膜炎用作科学研究,共26眼用于穿透性角膜移植。所有患者手术过程顺利,手术后3~4mo未发生排斥反应,角膜植片保持透明。手术后3~4mo角膜内皮细胞密度794~4 347（平均2 305±827）个/mm2,其中低于1 000个/mm2者1例（3.8%）,1 000~2 000个/mm2者9例（34.6%）,大于2 000个/mm2者16例（61.5%）。26例角膜移植受者年龄20~80（平均40.7±17.1）岁。手术前最佳矫正视力为光感（＋）~0.08（平均0.027±0.024）;手术后3~4mo最佳矫正视力为0.2~0.8（平均0.52±0.182）,两者比较差异有显著统计学意义（t=3.96,P〈0.01）。结论：DCD捐献角膜用作穿透性角膜移植供体具有较高的安全性。 |
| Abstract_FL | To test the safety of using cardiac death donation ( DCD ) corneas for penetrating keratoplasty surgery graft.METHODS:ln chronological order, suing DCD corneas penetrating keratoplasty, corneal endothelial cell density and best corrected visual acuity ( BCVA) were tested 3~4mo after surgery.RESULTS:A total of 14 cases of DCD while 26 corneas were included in this study. Donors age ranged 0. 5 ~61 years, averagely 38. 3 ± 15. 6 years. Causes of death included that 9 cases of traumatic brain injury, 2 cases myocardial infarction, 2 cases brain stem hemorrhage, 1 case of respiratory and circulatory failure. All 26 patients underwent penetrating keratoplasty, no rejection occurred and all grafts were transparent 3 ~ 4mo after surgery. Three to four months after surgery, corneal endothelial cell density ranged 794 ~ 4 347/mm2 , averaged 2 305 ± 827/mm2 , within which was only one case was lower than 1000/mm2 (3. 8%), while 9 cases ranged from 1000 ~ 2000/mm2 (34. 6%), 16 cases were higher than 2000/mm2 (61. 5%). The age of all the 26 receipts were from 20~80 years, mean 40. 7±17. 1 years. BCVA before surgery was light perception positive to 0. 08, with an average 0. 027±0. 024. Three to four months after surgery, BCVA were 0. 2~0. 8, with an average 0. 52± 0. 182 in contrast (t=3. 96, P<0. 001).CONCLUSlON:DCD donated corneas could be used for penetrating keratoplasty graft with high security. |
| Author | 徐晶 张虹 蒋继贫 徐玲娟 杜建芳 陈敏 马剑晴 李贵刚 |
| AuthorAffiliation | 华中科技大学同济医学院附属同济医院 手术室, 湖北省武汉市430030 华中科技大学同济医学院附属同济医院 眼科, 湖北省武汉市430030 华中科技大学同济医学院附属同济医院 器官移植科, 湖北省武汉市430030 |
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| Author_FL | Jing Xu Jian-Fang Du Ji-Pin Jiang Jian-Qing Ma Ling-Juan Xu Gui-Gang Li Hong Zhang Min Chen |
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| DOI | 10.3980/j.issn.1672-5123.2015.2.36 |
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| Keywords | best corrected visual acuity 心脏死亡后捐献 penetrating keratoplasty 最佳矫正视力 corneal endothelial cell cardiac death donation 穿透性角膜移植 角膜内皮细胞 |
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| Notes | cardiac death donation;penetrating keratoplasty;corneal endothelial cell;best corrected visual acuity 61-1419/R To test the safety of using cardiac death donation （ DCD ） corneas for penetrating keratoplasty surgery graft.METHODS：ln chronological order, suing DCD corneas penetrating keratoplasty, corneal endothelial cell density and best corrected visual acuity （ BCVA） were tested 3~4mo after surgery.RESULTS：A total of 14 cases of DCD while 26 corneas were included in this study. Donors age ranged 0. 5 ~61 years, averagely 38. 3 ± 15. 6 years. Causes of death included that 9 cases of traumatic brain injury, 2 cases myocardial infarction, 2 cases brain stem hemorrhage, 1 case of respiratory and circulatory failure. All 26 patients underwent penetrating keratoplasty, no rejection occurred and all grafts were transparent 3 ~ 4mo after surgery. Three to four months after surgery, corneal endothelial cell density ranged 794 ~ 4 347/mm2 , averaged 2 305 ± 827/mm2 , within which was only one case was lower than 1000/m |
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| PublicationTitle | 国际眼科杂志 |
| PublicationTitleAlternate | International Journal of Ophthalmology |
| PublicationTitle_FL | International Eye Science |
| PublicationYear | 2015 |
| Publisher | 华中科技大学同济医学院附属同济医院 手术室, 中国湖北省武汉市,430030%华中科技大学同济医学院附属同济医院 眼科, 中国湖北省武汉市,430030%华中科技大学同济医学院附属同济医院 器官移植科, 中国湖北省武汉市,430030 |
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| SubjectTerms | 心脏死亡后捐献 最佳矫正视力 穿透性角膜移植 角膜内皮细胞 |
| Title | 心脏死亡后捐献角膜用作穿透性角膜移植术供体的安全性研究 |
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