Cytotoxicity of resin composites containing bioactive glass fillers

• Published in: Dental materials Vol. 31; no. 2; pp. 195 - 203
• Main Authors: Salehi, Satin, Gwinner, Fernanda, Mitchell, John C, Pfeifer, Carmem, Ferracane, Jack L
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.02.2015
• Subjects: Advanced Basic Science; Analysis of variance; Bioactive glass; Biocompatibility; Bisphenol A-Glycidyl Methacrylate - toxicity; Cell Survival - drug effects; Cells, Cultured; Composite Resins - toxicity; Cytotoxicity; Degree of Conversion; Dental composites; Dental materials; Dental Materials - toxicity; Dental Pulp - cytology; Dentistry; Direct current; Disks; Exposure; Fillers; FTIR; Glass; In Vitro Techniques; Materials Testing; Polyethylene Glycols - toxicity; Polymethacrylic Acids - toxicity; Spectroscopy, Fourier Transform Infrared; Undifferentiated pulp cells (OD-21); Viability; Bioactive glass; Cytotoxicity; Dental composites; FTIR; Undifferentiated pulp cells (OD-21); Degree of Conversion
• ISSN: 0109-5641; 1879-0097
• DOI: 10.1016/j.dental.2014.12.004

Highlights • The results show that the composites, independent of composition, had equivalent potency in terms of reducing the viability of the cells in culture. • Soaking the composites for 7 days before exposing them to the cells suggested that the “toxic” components had been extracted and the materials were no longer cytotoxic. • The results demonstrate that the cytotoxicity of composites with and without BAG must predominantly be attributed to the release of residual monomers, and not to the presence of the BAG.