Epidemiological study of Kabuto Mountain virus, a novel uukuvirus, in Japan

Kabuto Mountain virus (KAMV), the new member of the genus Uukuvirus, was isolated from the tick Haemaphysalis flava in 2018 in Japan. To date, there is no information on KAMV infection in human and animals. Therefore, serological surveillance of the infection among humans and wild mammals was conduc...

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Published inJournal of Veterinary Medical Science Vol. 84; no. 1; pp. 82 - 89
Main Authors TRAN, Ngo T.B., SHIMODA, Hiroshi, MIZUNO, Junko, ISHIJIMA, Keita, YONEMITSU, Kenzo, MINAMI, Shohei, Supriyono, KURODA, Yudai, TATEMOTO, Kango, MENDOZA, Milagros V., TAKANO, Ai, MUTO, Masahiko, ISAWA, Haruhiko, SAWABE, Kyoko, HAYASAKA, Daisuke, MAEDA, Ken
Format Journal Article
LanguageEnglish
Published Japan JAPANESE SOCIETY OF VETERINARY SCIENCE 01.01.2022
Japan Science and Technology Agency
The Japanese Society of Veterinary Science
Subjects
Animals
Bunyaviridae - classification
Bunyaviridae - isolation & purification
Epidemiology
Haemaphysalis
Humans
Immunofluorescence
Japan
Kabuto Mountain virus
Phylogeny
tick
Ticks - virology
Uukuvirus
Virology
Viruses
Wildlife
zoonosis
Japan
uukuvirus
tick
zoonosis
Kabuto Mountain virus
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Summary:Kabuto Mountain virus (KAMV), the new member of the genus Uukuvirus, was isolated from the tick Haemaphysalis flava in 2018 in Japan. To date, there is no information on KAMV infection in human and animals. Therefore, serological surveillance of the infection among humans and wild mammals was conducted by virus-neutralization (VN) test and indirect immunofluorescence assay (IFA). Sera of 24 humans, 59 monkeys, 171 wild boars, 233 Sika deer, 7 bears, and 27 nutria in Yamaguchi Prefecture were analyzed by VN test. The positive ratio of humans, monkeys, wild boars, and Sika deer were 20.8%, 3.4%, 33.9% and 4.7%, respectively. No positive samples were detected in bears and nutria. The correlation coefficients between VN test and IFA in human, monkey, wild boar, and Sika deer sera were 0.5745, 0.7198, 0.9967 and 0.9525, respectively. In addition, KAMV was detected in one pool of Haemaphysalis formosensis ticks in Wakayama Prefecture. These results indicated that KAMV or KAMV-like virus is circulating among many wildlife and ticks, and that this virus incidentally infects humans.
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ISSN:0916-7250
1347-7439
1347-7439
DOI:10.1292/jvms.21-0577