Effectiveness of subunit influenza vaccination in the 2014–2015 season and residual effect of split vaccination in previous seasons

• Published in: Vaccine Vol. 34; no. 11; pp. 1350 - 1357
• Main Authors: Castilla, Jesús, Navascués, Ana, Fernández-Alonso, Mirian, Reina, Gabriel, Pozo, Francisco, Casado, Itziar, Guevara, Marcela, Martínez-Baz, Iván, Barricarte, Aurelio, Ezpeleta, Carmen
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 08.03.2016; Elsevier Limited
• Subjects: Adolescent; Adult; Aged; Aged, 80 and over; Allergy and Immunology; Case-Control Studies; Child; Child, Preschool; Chronic illnesses; Confidence intervals; Female; Health services; Hospitals; Humans; Influenza; Influenza A Virus, H1N1 Subtype; Influenza A Virus, H3N2 Subtype; Influenza B virus; Influenza vaccine; Influenza Vaccines - therapeutic use; Influenza virus; Influenza, Human - epidemiology; Influenza, Human - prevention & control; Laboratories; Male; Middle Aged; Orthomyxoviridae; Population; Proteins; Seasons; Sentinel Surveillance; Spain - epidemiology; Split-virion vaccine; Subunit vaccine; Vaccination - statistics & numerical data; Vaccine effectiveness; Vaccines; Vaccines, Subunit - therapeutic use; Viruses; Young Adult; Spain; Spain, Navarra; ANE, Spain; Split-virion vaccine; Subunit vaccine; Influenza vaccine; Influenza; Vaccine effectiveness
• ISSN: 0264-410X; 1873-2518
• DOI: 10.1016/j.vaccine.2016.01.054

Highlights • Effectiveness of influenza vaccines was evaluated in Spain in the 2014–2015 season. • Inpatient and outpatient cases with confirmed influenza were the outcome variable. • The overall effect of the influenza subunit vaccine in the current season was low. • Split influenza vaccine in the two previous seasons showed considerable protection. • The results suggest interference between both vaccine types.