Photoswitching the Cytotoxic Properties of Platinum(II) Compounds

The photoactivation of potential anticancer metal complexes is a hot topic of current research as it may lead to the development of more selective drugs. Photoactivated chemotherapy (PACT) with coordination compounds is usually based on a (photo)chemical reaction taking place at the metal center. He...

Full description

Saved in:
Bibliographic Details
Published inAngewandte Chemie (International ed.) Vol. 54; no. 15; pp. 4561 - 4565
Main Authors Presa, Andreu, Brissos, Rosa F., Caballero, Ana Belén, Borilovic, Ivana, Korrodi-Gregório, Luís, Pérez-Tomás, Ricardo, Roubeau, Olivier, Gamez, Patrick
Format Journal Article
LanguageEnglish
Published Weinheim WILEY-VCH Verlag 07.04.2015
WILEY‐VCH Verlag
Wiley Subscription Services, Inc
EditionInternational ed. in English
Subjects
Anticancer properties
Antineoplastic Agents - chemistry
Antineoplastic Agents - pharmacology
cancer
Cell Line, Tumor
Coordination compounds
Cytotoxicity
DNA - metabolism
Drug Design
Exact solutions
Humans
Lead (metal)
Ligands
Mathematical analysis
Models, Molecular
Neoplasms - drug therapy
Neoplasms - metabolism
Organoplatinum Compounds - chemistry
Organoplatinum Compounds - pharmacology
photochemistry
Photosensitizing Agents - chemistry
Photosensitizing Agents - pharmacology
platinum
Strategy
Switches
Toxicology
platinum
cancer
drug design
photochemistry
cytotoxicity
Online AccessGet full text

Cover

More Information
Summary:The photoactivation of potential anticancer metal complexes is a hot topic of current research as it may lead to the development of more selective drugs. Photoactivated chemotherapy (PACT) with coordination compounds is usually based on a (photo)chemical reaction taking place at the metal center. Herein, a new strategy is exploited that consists of “photomodifying” a ligand coordinated to metal ions. Platinum(II) complexes from photoswitchable 1,2‐dithienylethene‐containing ligands have been prepared, which exhibit two interconvertible photoisomeric forms that present distinct DNA‐interacting properties and cytotoxic behaviors. Toxic switch: The photoswitchable open and closed forms of 1,2‐dithienylethene‐based platinum(II) compounds exhibit distinct DNA‐interacting and cytotoxic properties, which may lead to a new class of potential photoactivatable anticancer agents.
Bibliography:EU
ArticleID:ANIE201412157
La Marató de TV3 Foundation - No. 20132730
Fundação para a Ciência e Tecnologia of the Portuguese Ministry of Science and Higher Education - No. SFRH/BPD/91766/2012
istex:18DF43ED48086CF16CBCA2E77ACAE3679C537C14
COST Action
Spanish government
ark:/67375/WNG-LZHJTRC6-R
P.G. acknowledges the Institució Catalana de Recerca i Estudis Avançats, the Ministerio de Economía y Competitividad of Spain (Project CTQ2011-27929-C02-01), and COST Action CM1105. This work was partially supported by a grant from the Spanish government, the EU (FEDER) (FIS PI13/00089), La Marató de TV3 Foundation (20132730), and an individual grant from Fundação para a Ciência e Tecnologia of the Portuguese Ministry of Science and Higher Education to L.K.G. (SFRH/BPD/91766/2012).
Ministerio de Economía y Competitividad of Spain - No. CTQ2011-27929-C02-01
P.G. acknowledges the Institució Catalana de Recerca i Estudis Avançats, the Ministerio de Economía y Competitividad of Spain (Project CTQ2011‐27929‐C02‐01), and COST Action CM1105. This work was partially supported by a grant from the Spanish government, the EU (FEDER) (FIS PI13/00089), La Marató de TV3 Foundation (20132730), and an individual grant from Fundação para a Ciência e Tecnologia of the Portuguese Ministry of Science and Higher Education to L.K.G. (SFRH/BPD/91766/2012).
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201412157