Impact of childhood and recent traumatic events on the clinical presentation of overactive bladder

• Published in: Neurourology and urodynamics Vol. 35; no. 8; pp. 1017 - 1023
• Main Authors: Lai, H. Henry, Morgan, Clinton D., Vetter, Joel, Andriole, Gerald L.
• Format: Journal Article
• Language: English
• Published: United States Blackwell Publishing Ltd 01.11.2016; Wiley Subscription Services, Inc
• Subjects: Adult; Age Factors; Aged; Child; Child Abuse, Sexual; childhood trauma; Cost of Illness; Female; Humans; Life Change Events; Male; Mental Health; Middle Aged; Neuropsychological Tests; overactive bladder; Pain - complications; Pain - psychology; Prevalence; Quality of Life; Urinary Bladder, Overactive - epidemiology; Urinary Bladder, Overactive - etiology; Urinary Bladder, Overactive - psychology; Wounds and Injuries - complications; Wounds and Injuries - epidemiology; Wounds and Injuries - psychology; childhood trauma; overactive bladder
• ISSN: 0733-2467; 1520-6777; 1520-6777
• DOI: 10.1002/nau.22872

Aims (1) To describe the Prevalence of childhood and recent trauma in patients with overactive bladder (OAB), and (2) assess the impact of traumatic events on the clinical presentation and the severity of OAB symptoms, quality of life, and psychosocial health. Methods Patients diagnosed with OAB (n = 51) and age‐matched healthy controls (n = 30) were administered the Childhood Traumatic Events Scale and Recent Traumatic Events Scale, assessing exposure and perceived impact of common traumatic events. Among OAB patients, validated instruments were administered to correlate traumatic exposure to evaluate adult urinary symptoms (ICIQ‐UI, ICIQ‐OAB, OAB‐q, UDI‐6, IIQ‐7, USS), mood dysregulation (HADS), sleep and fatigue (PROMIS), and Psychological stress (PSS). Results Childhood sexual trauma was more prevalent in patients with OAB compared to controls (29.4% vs. 6.7%, P = 0.041). OAB patients also rated their childhood sexual exposure as more traumatic compared to controls (mean ratings of 1.7 vs. 0.4, P = 0.050). There was no difference in childhood deaths (P = 0.24), parental upheaval (P = 0.87), violence (P = 0.099), illness/injury (P = 0.683), or any recent traumatic events between OAB and control subjects. Childhood trauma predicted worse bladder pain (P = 0.005), worse non‐urologic pain (P = 0.017), poorer mood (P = 0.001), higher anxiety (P = 0.029), higher physical symptom burden (P < 0.001), and higher psychological stress (P < 0.039). However, childhood trauma did not correlate with the severity of OAB symptoms (urgency, frequency, incontinence). Conclusions Thirty percent of OAB patients reported childhood sexual trauma. These patients report more pain symptoms, poorer mood, and greater somatic burden. These data highlight the potentiating role of psychosocial stressors from childhood in the adult suffering from OAB. Neurourol. Urodynam. 35:1017–1023, 2016. © 2015 Wiley periodicals, Inc.