Recent Developments in the Trifluoromethylation of Alkynes

• Published in: Chemistry : a European journal Vol. 21; no. 21; pp. 7648 - 7661
• Main Authors: Gao, Pin, Song, Xian-Rong, Liu, Xue-Yuan, Liang, Yong-Min
• Format: Journal Article
• Language: English
• Published: Weinheim WILEY-VCH Verlag 18.05.2015; WILEY‐VCH Verlag; Wiley Subscription Services, Inc
• Subjects: alkyne; Alkynes; Alkynes - chemical synthesis; Alkynes - chemistry; Catalysis; Chemistry; Chemistry Techniques, Synthetic - methods; Construction; Covering; difunctionalization; Formations; Halogenation; Hydrocarbons, Fluorinated - chemical synthesis; Hydrocarbons, Fluorinated - chemistry; Methylation; radical reactions; Radicals; synthetic methods; trifluoromethylation; radical reactions; difunctionalization; alkyne; trifluoromethylation; synthetic methods
• ISSN: 0947-6539; 1521-3765
• DOI: 10.1002/chem.201406432

In the last few years, the development of versatile methodologies to incorporate trifluoromethyl groups into organic molecules has attracted significant attention in synthetic chemistry. This review gives an overview over the development on the trifluoromethylation of alkynes, which have not been solely discussed before. Formation of diverse C(sp, sp2, sp3)CF3 bonds are all covered in this review. Versatile methodologies for the incorporation of trifluoromethyl groups into organic molecules have attracted significant attention in synthetic chemistry. This Minireview highlights the recent efforts on the development of trifluoromethylation of alkynes to construct various diverse C(sp, sp2, sp3)CF3 bonds by radical processes, or through transition‐metal catalysis by using nucleophilic or electrophilic trifluoromethylation reagents (see scheme).