It’s risky to wander in September: Modelling the epidemic potential of Rift Valley fever in a Sahelian setting

• Published in: Epidemics Vol. 33; p. 100409
• Main Authors: Cecilia, Hélène, Métras, Raphaëlle, Fall, Assane Gueye, Lo, Modou Moustapha, Lancelot, Renaud, Ezanno, Pauline
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.12.2020; Elsevier
• Subjects: Aedes - virology; Animals; Basic reproduction number; Cattle; Culex - virology; Disease Outbreaks; Disease Vectors; Ecosystem; Epidemics; Humans; Infectious Disease; Internal Medicine; Life Sciences; Mathematical modelling; Mosquito Vectors; Rift Valley Fever - epidemiology; Rift Valley Fever - transmission; Rift Valley Fever - virology; Rift Valley fever virus; Risk map; Seasons; Senegal - epidemiology; Sheep; Temperature; Vector-borne disease; Senegal; Basic reproduction number; Rift Valley fever virus; Mathematical modelling; Vector-borne disease; Risk map
• ISSN: 1755-4365; 1878-0067; 1878-0067
• DOI: 10.1016/j.epidem.2020.100409

[Display omitted] •September is a period of high RVF epidemic potential in northern Senegal.•Locations at risk of RVF epidemics vary across years.•Decreased vector densities do not greatly reduce RVF epidemic potential of at-risk locations.•Herd immunity in cattle reduces more RVF transmission than in small ruminants.•Vector feeding preferences and the length of their gonotrophic cycle are key parameters. Estimating the epidemic potential of vector-borne diseases, along with the relative contribution of underlying mechanisms, is crucial for animal and human health worldwide. In West African Sahel, several outbreaks of Rift Valley fever (RVF) have occurred over the last decades, but uncertainty remains about the conditions necessary to trigger these outbreaks. We use the basic reproduction number (R0) as a measure of RVF epidemic potential in northern Senegal, and map its value in two distinct ecosystems, namely the Ferlo and the Senegal River delta and valley. We consider three consecutive rainy seasons (July-November 2014, 2015 and 2016) and account for several vector and animal species. We parametrize our model with estimates of Aedes vexans arabiensis, Culex poicilipes, Culex tritaeniorhynchus, cattle, sheep and goat abundances. The impact of RVF virus introduction is assessed every week over northern Senegal. We highlight September as the period of highest epidemic potential in northern Senegal, resulting from distinct dynamics in the two study areas. Spatially, in the seasonal environment of the Ferlo, we observe that high-risk locations vary between years. We show that decreased vector densities do not greatly reduce R0 and that cattle immunity has a greater impact on reducing transmission than small ruminant immunity. The host preferences of vectors and the temperature-dependent time interval between their blood meals are crucial parameters needing further biological investigations.