Two cases of retroperitoneal hematoma caused by combination of anticoagulant therapy and 5-fluorouracil

We reported two cases of retroperitoneal hematoma in patients who received a combination of anticoagulant therapy and 5-fluorouracil (5-FU). We should be aware of the possible interaction of this combination therapy and monitor prothrombin time (PT) prolongation. CT is useful for evaluation of the d...

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Bibliographic Details
Published inThe Journal of Medical Investigation Vol. 52; no. 1,2; pp. 114 - 117
Main Authors Murase, Tomoya, Minato, Masako, Furutani, Kaori, Tsujikawa, Tetsuya, Morita, Naomi, Nishitani, Hiromu, Otsuka, Hideki, Furutani, Syunnsuke, Yoneda, Kazuhide, Tagashira, Hiroshi, Kashihara, Kennichi
Format Journal Article
LanguageEnglish
Published Japan The University of Tokushima Faculty of Medicine 01.02.2005
Subjects
5-FU
Aged
Anticoagulants - administration & dosage
Anticoagulants - adverse effects
Antimetabolites, Antineoplastic - administration & dosage
Antimetabolites, Antineoplastic - adverse effects
Colonic Neoplasms - drug therapy
Drug Interactions
Esophageal Neoplasms - drug therapy
Fluorouracil - administration & dosage
Fluorouracil - adverse effects
Hematoma - diagnosis
Hematoma - etiology
Humans
Male
retroperitoneal hematoma
Retroperitoneal Space
warfarin
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ISSN1343-1420
1349-6867
DOI10.2152/jmi.52.114

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Summary:We reported two cases of retroperitoneal hematoma in patients who received a combination of anticoagulant therapy and 5-fluorouracil (5-FU). We should be aware of the possible interaction of this combination therapy and monitor prothrombin time (PT) prolongation. CT is useful for evaluation of the disease. J. Med. Invest. 52: 114-117, February, 2005
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ISSN:1343-1420
1349-6867
DOI:10.2152/jmi.52.114