Stimulatory Action of Lisuride on Dopamine-Sensitive Adenylate Cyclase in the Rat Striatal Homogenate

Effect of lisuride, an ergot derivative of isolysergic structure, on dopamine-sensitive adenylate cyclase was studied in the homogenate of rat corpus striatum. Stimulatory action of lisuride, similar to the actions of dopamine and apomorphine, on striatal adenylate cyclase was potentiated significan...

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Bibliographic Details
Published inJapanese journal of pharmacology Vol. 30; no. 5; pp. 629 - 639
Main Authors Azuma, Haruyoshi, Oshino, Nozomu
Format Journal Article
LanguageEnglish
Published Japan The Japanese Pharmacological Society 01.01.1980
Subjects
Adenylyl Cyclases - metabolism
Animals
Corpus Striatum - enzymology
Dopamine - metabolism
Drug Synergism
Ergolines - pharmacology
Haloperidol - pharmacology
In Vitro Techniques
Lisuride - antagonists & inhibitors
Lisuride - pharmacology
Male
Nucleotides - pharmacology
Rats
Stimulation, Chemical
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Summary:Effect of lisuride, an ergot derivative of isolysergic structure, on dopamine-sensitive adenylate cyclase was studied in the homogenate of rat corpus striatum. Stimulatory action of lisuride, similar to the actions of dopamine and apomorphine, on striatal adenylate cyclase was potentiated significantly by guanosine triphosphate (GTP) and by guanylyl imidodiphosphate (GMP-PNP), although with lisuride alone, there was only a slight stimulation. The maximal stimulation attained in the presence of GTP corresponded to about 1.4 times the basal rate of cyclic AMP formation in the homogenate and was abolished by an addition of haloperidol. Lisuride at a concentration above 3µM inhibited stimulation of cyclic AMP formation by dopamine. The effect of lisuride and the extent of potentiation by the guanyl nucleotides were almost comparable to the effects of apomorphine, under corresponding conditions. Thus, lisuride, like apomorphine, acts as a partial agonist-antagonist, and has the ability to stimulate the dopamine-sensitive adenylate cyclase in the rat corpus striatum.
ISSN:0021-5198
1347-3506
DOI:10.1254/jjp.30.629