R-(-)-carvone Attenuated Doxorubicin Induced Cardiotoxicity In Vivo and Potentiated Its Anticancer Toxicity In Vitro

• Published in: Balkan medical journal Vol. 37; no. 2; pp. 98 - 103
• Main Authors: Abbas, Manal Mohammad, Kandil, Yasser İbrahim, Abbas, Manal Ahmad
• Format: Journal Article
• Language: English
• Published: Turkey Galenos Yayinevi Tic. Ltd 01.03.2020; Trakya Üniversitesi; Galenos Publishing; Galenos Publishing House
• Subjects: Animal experimentation; Anthracyclines; Antineoplastic agents; Cancer; Cancer treatment; cardiotoxicity; catalase; Chemotherapy; doxorubicin; h9c2; mcf 7; Original; r-(-)-carvone; Tıp; Toxicity; Tumors; Türkiye; Edirne; H9C2; Cardiotoxicity; doxorubicin; MCF 7; R-(-)-carvone; catalase
• ISSN: 2146-3123; 2146-3131
• DOI: 10.4274/balkanmedj.galenos.2019.2019.7.117

Doxorubicin is one of the most potent broad-spectrum antitumor and chemotherapeutic agents. However, it produces cardiotoxicity. To investigate whether R-(-)-carvone exerts a cardioprotective effect against doxorubicin toxicity and . Cell culture and animal experiment. The synergistic effect of R-(-)-carvone with doxorubicin was evaluated in the MCF 7 cancer cell line while its protective effect against doxorubicin toxicity was evaluated in the normal heart cell line (H9C2) and . Furthermore, the mechanism of its cardioprotective effect was studied. R-(-)-carvone exerted cytotoxic action on the MCF 7 cancer cell line with an IC value of 14.22 μM and potentiated the cytotoxic action of doxorubicin, while it decreased the toxicity of doxorubicin on a normal heart cell line. In BALB/c mice, R-(-)-carvone protected the heart from the toxic action of doxorubicin, as was evident by biochemical and histological studies. The protective effect of R-(-)-carvone on the H9C2 heart cell line and on heart was due to an increase in catalase activity. R-(-)-carvone has synergistic anticancer action with doxorubicin on the MCF 7 cell line while decreasing its cardiotoxicity.