IL-2 controls trafficking receptor gene expression and Th2 response for skin and lung inflammation

• Published in: Clinical immunology (Orlando, Fla.) Vol. 145; no. 1; pp. 82 - 88
• Main Authors: Ju, Shyr-Te, Sharma, Rahul, Gaskin, Felicia, Fu, Shu Man
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.10.2012
• Subjects: Allergy and Immunology; Animals; Autoimmune diseases; CD4 antigen; CD4 Antigens - genetics; CD4 Antigens - immunology; Cell Movement - genetics; Cell Movement - immunology; Cytokines - biosynthesis; Cytokines - immunology; Foxp3 protein; Gene expression; Gene Expression - immunology; Helper cells; Inflammation; Inflammatory diseases; Interleukin 2; Interleukin-2 - genetics; Interleukin-2 - immunology; Lung; Lung - immunology; Lung - pathology; Lymphocyte Activation - genetics; Lymphocyte Activation - immunology; Lymphocytes T; Mice; Mice, Knockout; Migration; Pneumonia - genetics; Pneumonia - immunology; Pneumonia - pathology; Protein transport; Receptors, Cell Surface - genetics; Receptors, Cell Surface - immunology; Reviews; Scurfy mice; Skin; Skin - immunology; Skin - pathology; Skin diseases; Th1 Cells - immunology; Th1 Cells - pathology; Th2 Cells - immunology; Th2 Cells - pathology; Treg; Inflammation; Scurfy mice; Autoimmune diseases; MOI; Treg; Multi-organ inflammation

Both Il2−/− mice and Scurfy (Sf) mutant mice that are deficient in FoxP3, develop multi-organ inflammation but only the latter display severe skin and lung inflammation. In contrast, Sf.Il2−/− double mutant mice do not display skin inflammation and markedly reduced lung inflammation. In this review,...