IL-2 controls trafficking receptor gene expression and Th2 response for skin and lung inflammation

• Published in: Clinical immunology (Orlando, Fla.) Vol. 145; no. 1; pp. 82 - 88
• Main Authors: Ju, Shyr-Te, Sharma, Rahul, Gaskin, Felicia, Fu, Shu Man
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.10.2012
• Subjects: Allergy and Immunology; Animals; Autoimmune diseases; CD4 antigen; CD4 Antigens - genetics; CD4 Antigens - immunology; Cell Movement - genetics; Cell Movement - immunology; Cytokines - biosynthesis; Cytokines - immunology; Foxp3 protein; Gene expression; Gene Expression - immunology; Helper cells; Inflammation; Inflammatory diseases; Interleukin 2; Interleukin-2 - genetics; Interleukin-2 - immunology; Lung; Lung - immunology; Lung - pathology; Lymphocyte Activation - genetics; Lymphocyte Activation - immunology; Lymphocytes T; Mice; Mice, Knockout; Migration; Pneumonia - genetics; Pneumonia - immunology; Pneumonia - pathology; Protein transport; Receptors, Cell Surface - genetics; Receptors, Cell Surface - immunology; Reviews; Scurfy mice; Skin; Skin - immunology; Skin - pathology; Skin diseases; Th1 Cells - immunology; Th1 Cells - pathology; Th2 Cells - immunology; Th2 Cells - pathology; Treg; Inflammation; Scurfy mice; Autoimmune diseases; MOI; Treg; Multi-organ inflammation
• ISSN: 1521-6616; 1521-7035; 1521-7035
• DOI: 10.1016/j.clim.2012.07.015

Both Il2−/− mice and Scurfy (Sf) mutant mice that are deficient in FoxP3, develop multi-organ inflammation but only the latter display severe skin and lung inflammation. In contrast, Sf.Il2−/− double mutant mice do not display skin inflammation and markedly reduced lung inflammation. In this review, we summarize our recent findings based on microarray, q-PCR and functional studies of 10 Sf double mutant mice. These studies revealed novel pro-inflammatory functions of IL-2 in regulating inflammation in an organ-specific manner. IL-2 exerts its “organ-specific” pro-inflammatory function by regulating the migration and retention of CD4+ T-cells (both Th1 and Th2) specifically to the skin and lung. In addition, IL-2 is also required for regulating the Th2 cytokine response during T-cell activation. Further studies on these IL-2‐regulated genes will help in identifying novel targets for intervention in inflammatory diseases of skin and lung. ► IL‐2 is an inflammatory cytokine for skin and lung as well as T‐cell growth. ► Th1 cytokine and related TRGs are insufficient to induce skin and lung inflammation. ► IL‐2 is required for the expression of many of the Th2 related traffic genes. ► IL-2 controls the expression of the adhesion molecule ITGAE, CD103.