IL-2 controls trafficking receptor gene expression and Th2 response for skin and lung inflammation

Both Il2−/− mice and Scurfy (Sf) mutant mice that are deficient in FoxP3, develop multi-organ inflammation but only the latter display severe skin and lung inflammation. In contrast, Sf.Il2−/− double mutant mice do not display skin inflammation and markedly reduced lung inflammation. In this review,...

Full description

Saved in:

Bibliographic Details
Published in	Clinical immunology (Orlando, Fla.) Vol. 145; no. 1; pp. 82 - 88
Main Authors	Ju, Shyr-Te, Sharma, Rahul, Gaskin, Felicia, Fu, Shu Man
Format	Journal Article
Language	English
Published	United States Elsevier Inc 01.10.2012
Subjects	Allergy and Immunology Animals Autoimmune diseases CD4 antigen CD4 Antigens - genetics CD4 Antigens - immunology Cell Movement - genetics Cell Movement - immunology Cytokines - biosynthesis Cytokines - immunology Foxp3 protein Gene expression Gene Expression - immunology Helper cells Inflammation Inflammatory diseases Interleukin 2 Interleukin-2 - genetics Interleukin-2 - immunology Lung Lung - immunology Lung - pathology Lymphocyte Activation - genetics Lymphocyte Activation - immunology Lymphocytes T Mice Mice, Knockout Migration Pneumonia - genetics Pneumonia - immunology Pneumonia - pathology Protein transport Receptors, Cell Surface - genetics Receptors, Cell Surface - immunology Reviews Scurfy mice Skin Skin - immunology Skin - pathology Skin diseases Th1 Cells - immunology Th1 Cells - pathology Th2 Cells - immunology Th2 Cells - pathology Treg Inflammation Scurfy mice Autoimmune diseases MOI Treg Multi-organ inflammation
Online Access	Get full text

Cover

Loading…

Abstract	Both Il2−/− mice and Scurfy (Sf) mutant mice that are deficient in FoxP3, develop multi-organ inflammation but only the latter display severe skin and lung inflammation. In contrast, Sf.Il2−/− double mutant mice do not display skin inflammation and markedly reduced lung inflammation. In this review, we summarize our recent findings based on microarray, q-PCR and functional studies of 10 Sf double mutant mice. These studies revealed novel pro-inflammatory functions of IL-2 in regulating inflammation in an organ-specific manner. IL-2 exerts its “organ-specific” pro-inflammatory function by regulating the migration and retention of CD4+ T-cells (both Th1 and Th2) specifically to the skin and lung. In addition, IL-2 is also required for regulating the Th2 cytokine response during T-cell activation. Further studies on these IL-2‐regulated genes will help in identifying novel targets for intervention in inflammatory diseases of skin and lung. ► IL‐2 is an inflammatory cytokine for skin and lung as well as T‐cell growth. ► Th1 cytokine and related TRGs are insufficient to induce skin and lung inflammation. ► IL‐2 is required for the expression of many of the Th2 related traffic genes. ► IL-2 controls the expression of the adhesion molecule ITGAE, CD103.
AbstractList	Both Il2-/-mice and Scurfy (Sf) mutant mice that are deficient in FoxP3, develop multi-organ inflammation but only the latter display severe skin and lung inflammation. In contrast, Sf.Il2-/- double mutant mice do not display skin inflammation and markedly reduced lung inflammation. In this review, we summarize our recent findings based on microarray, q-PCR and functional studies of 10 Sf double mutant mice. These studies revealed novel pro-inflammatory functions of IL-2 in regulating inflammation in an organ-specific manner. IL-2 exerts its "organ-specific" pro-inflammatory function by regulating the migration and retention of CD4+ T-cells (both Th1 and Th2) specifically to the skin and lung. In addition, IL-2 is also required for regulating the Th2 cytokine response during T-cell activation. Further studies on these IL-2-regulated genes will help in identifying novel targets for intervention in inflammatory diseases of skin and lung. Both Il2 −/− mice and Scurfy (Sf) mutant mice that are deficient in FoxP3, develop multi-organ inflammation but only the latter display severe skin and lung inflammation. In contrast, Sf.Il2 −/− double mutant mice do not display skin inflammation and markedly reduced lung inflammation. In this review, we summarize our recent findings based on microarray, q -PCR and functional studies of 10 Sf double mutant mice. These studies revealed novel pro-inflammatory functions of IL-2 in regulating inflammation in an organ-specific manner. IL-2 exerts its “organ-specific” pro-inflammatory function by regulating the migration and retention of CD4 + T-cells (both Th1 and Th2) specifically to the skin and lung. In addition, IL-2 is also required for regulating the Th2 cytokine response during T-cell activation. Further studies on these IL-2 –regulated genes will help in identifying novel targets for intervention in inflammatory diseases of skin and lung. Abstract Both Il2 −/− mice and Scurfy (Sf) mutant mice that are deficient in FoxP3, develop multi-organ inflammation but only the latter display severe skin and lung inflammation. In contrast, Sf.Il2 −/− double mutant mice do not display skin inflammation and markedly reduced lung inflammation. In this review, we summarize our recent findings based on microarray, q -PCR and functional studies of 10 Sf double mutant mice. These studies revealed novel pro-inflammatory functions of IL-2 in regulating inflammation in an organ-specific manner. IL-2 exerts its “organ-specific” pro-inflammatory function by regulating the migration and retention of CD4+ T-cells (both Th1 and Th2) specifically to the skin and lung. In addition, IL-2 is also required for regulating the Th2 cytokine response during T-cell activation. Further studies on these IL-2‐regulated genes will help in identifying novel targets for intervention in inflammatory diseases of skin and lung. Both Il2−/− mice and Scurfy (Sf) mutant mice that are deficient in FoxP3, develop multi-organ inflammation but only the latter display severe skin and lung inflammation. In contrast, Sf.Il2−/− double mutant mice do not display skin inflammation and markedly reduced lung inflammation. In this review, we summarize our recent findings based on microarray, q-PCR and functional studies of 10 Sf double mutant mice. These studies revealed novel pro-inflammatory functions of IL-2 in regulating inflammation in an organ-specific manner. IL-2 exerts its “organ-specific” pro-inflammatory function by regulating the migration and retention of CD4+ T-cells (both Th1 and Th2) specifically to the skin and lung. In addition, IL-2 is also required for regulating the Th2 cytokine response during T-cell activation. Further studies on these IL-2‐regulated genes will help in identifying novel targets for intervention in inflammatory diseases of skin and lung. ► IL‐2 is an inflammatory cytokine for skin and lung as well as T‐cell growth. ► Th1 cytokine and related TRGs are insufficient to induce skin and lung inflammation. ► IL‐2 is required for the expression of many of the Th2 related traffic genes. ► IL-2 controls the expression of the adhesion molecule ITGAE, CD103. Both Il2(-/-) mice and Scurfy (Sf) mutant mice that are deficient in FoxP3, develop multi-organ inflammation but only the latter display severe skin and lung inflammation. In contrast, Sf.Il2(-/-) double mutant mice do not display skin inflammation and markedly reduced lung inflammation. In this review, we summarize our recent findings based on microarray, q-PCR and functional studies of 10 Sf double mutant mice. These studies revealed novel pro-inflammatory functions of IL-2 in regulating inflammation in an organ-specific manner. IL-2 exerts its "organ-specific" pro-inflammatory function by regulating the migration and retention of CD4(+) T-cells (both Th1 and Th2) specifically to the skin and lung. In addition, IL-2 is also required for regulating the Th2 cytokine response during T-cell activation. Further studies on these IL-2-regulated genes will help in identifying novel targets for intervention in inflammatory diseases of skin and lung.Both Il2(-/-) mice and Scurfy (Sf) mutant mice that are deficient in FoxP3, develop multi-organ inflammation but only the latter display severe skin and lung inflammation. In contrast, Sf.Il2(-/-) double mutant mice do not display skin inflammation and markedly reduced lung inflammation. In this review, we summarize our recent findings based on microarray, q-PCR and functional studies of 10 Sf double mutant mice. These studies revealed novel pro-inflammatory functions of IL-2 in regulating inflammation in an organ-specific manner. IL-2 exerts its "organ-specific" pro-inflammatory function by regulating the migration and retention of CD4(+) T-cells (both Th1 and Th2) specifically to the skin and lung. In addition, IL-2 is also required for regulating the Th2 cytokine response during T-cell activation. Further studies on these IL-2-regulated genes will help in identifying novel targets for intervention in inflammatory diseases of skin and lung.
Author	Fu, Shu Man Gaskin, Felicia Sharma, Rahul Ju, Shyr-Te
AuthorAffiliation	2 Department of Microbiology, Immunology, and Cancer Biology, University of Virginia, Charlottesville, Virginia, USA 1 Center for Immunity, Inflammation and Regenerative Medicine and Division of Rheumatology and Immunology, Department of Medicine, University of Virginia, Charlottesville, Virginia, USA 3 Department of Psychiatry and Neurobehavioral Sciences, School of Medicine, University of Virginia, Charlottesville, Virginia, USA
AuthorAffiliation_xml	– name: 3 Department of Psychiatry and Neurobehavioral Sciences, School of Medicine, University of Virginia, Charlottesville, Virginia, USA – name: 1 Center for Immunity, Inflammation and Regenerative Medicine and Division of Rheumatology and Immunology, Department of Medicine, University of Virginia, Charlottesville, Virginia, USA – name: 2 Department of Microbiology, Immunology, and Cancer Biology, University of Virginia, Charlottesville, Virginia, USA
Author_xml	– sequence: 1 givenname: Shyr-Te surname: Ju fullname: Ju, Shyr-Te organization: Center for Immunity, Inflammation and Regenerative Medicine and Division of Rheumatology and Immunology, Department of Medicine, University of Virginia, Charlottesville, VA, USA – sequence: 2 givenname: Rahul surname: Sharma fullname: Sharma, Rahul organization: Center for Immunity, Inflammation and Regenerative Medicine and Division of Rheumatology and Immunology, Department of Medicine, University of Virginia, Charlottesville, VA, USA – sequence: 3 givenname: Felicia surname: Gaskin fullname: Gaskin, Felicia organization: Department of Psychiatry and Neurobehavioral Sciences, School of Medicine, University of Virginia, Charlottesville, VA, USA – sequence: 4 givenname: Shu Man surname: Fu fullname: Fu, Shu Man email: sf2e@virginia.edu organization: Center for Immunity, Inflammation and Regenerative Medicine and Division of Rheumatology and Immunology, Department of Medicine, University of Virginia, Charlottesville, VA, USA
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/22940635$$D View this record in MEDLINE/PubMed
BookMark	eNqNkk1v1DAQhiPUin7AH-CAcuSSMHZiZ4NQJVTxUWklDpSz5TjjrbeJvdhJRf89s90topUonGx53uf12O-cZAc-eMyyVwxKBky-XZdmcGPJgfESmhKYeJYdM8FZ0UAlDvZ7KZk8yk5SWgOA4Fw-z444b2uQlTjOuotlwXMT_BTDkPIpamuduXZ-lUc0uJlCzFfoMcefm4gpueBz7fv88oqTIG2CT5hbEiVi7irDTKzzdtDjqCfSv8gOrR4Svtyvp9n3Tx8vz78Uy6-fL84_LAtDHU5FVbOmN6JnULfG2gVvhO06A2BEJ2rDEVsOi1oL2dJZr5HLjttWiK7vLMqmOs3Odr6buRuxN0hv0oPaRDfqeKuCduphxbsrtQo3qqrrmlzJ4M3eIIYfM6ZJjS4ZHAbtMcxJMWirWjbQ8v-Q1gyAcyFJ-vrPtn73c58BCRY7gYkhpYhWGTfd_Rx16QbyUtu41Vpt41bbuBU0iuImlD9C792fhN7vIKQwbhxGlYxDb7B3FPmk-uCexs8e4STxzujhGm8xrcMcPcWsmErEqG_bIdzOIOMArIUFGbz7u8G_bv8FU2ftPA
CitedBy_id	crossref_primary_10_3389_fimmu_2017_01628 crossref_primary_10_1155_2020_6243019 crossref_primary_10_1186_s12989_016_0159_z crossref_primary_10_1016_j_fct_2023_114032 crossref_primary_10_1080_01902148_2019_1684596 crossref_primary_10_1002_btpr_1785 crossref_primary_10_1021_acs_chemrev_8b00396 crossref_primary_10_1002_btpr_1861 crossref_primary_10_3390_cells11121884 crossref_primary_10_1007_s11739_024_03699_0 crossref_primary_10_1111_wrr_12252 crossref_primary_10_1681_ASN_2016121272 crossref_primary_10_1002_ptr_8222 crossref_primary_10_1007_s13337_021_00705_3 crossref_primary_10_1073_pnas_1313547110 crossref_primary_10_15570_actaapa_2018_20 crossref_primary_10_3389_fphar_2021_806612 crossref_primary_10_1002_pros_24584
Cites_doi	10.4049/jimmunol.1002677 10.4049/jimmunol.179.12.8035 10.1038/83707 10.1111/j.1398-9995.2009.02015.x 10.1016/j.jaci.2005.08.046 10.1172/JCI6993 10.1016/j.jaut.2011.01.001 10.1016/0092-8674(93)80067-O 10.1016/S0092-8674(00)80438-9 10.1002/eji.1830251111 10.1038/83784 10.1073/pnas.0400339101 10.4049/jimmunol.136.7.2348 10.1172/JCI40591 10.4049/jimmunol.181.5.3285 10.1093/intimm/12.12.1659 10.1084/jem.187.12.2009 10.1016/j.jaut.2012.02.001
ContentType	Journal Article
Copyright	2012 Elsevier Inc. Elsevier Inc. Copyright © 2012 Elsevier Inc. All rights reserved. 2012 Elsevier Inc. All rights reserved. 2012
Copyright_xml	– notice: 2012 Elsevier Inc. – notice: Elsevier Inc. – notice: Copyright © 2012 Elsevier Inc. All rights reserved. – notice: 2012 Elsevier Inc. All rights reserved. 2012
DBID	AAYXX CITATION CGR CUY CVF ECM EIF NPM 7X8 7T5 H94 5PM
DOI	10.1016/j.clim.2012.07.015
DatabaseName	CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic Immunology Abstracts AIDS and Cancer Research Abstracts PubMed Central (Full Participant titles)
DatabaseTitle	CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic AIDS and Cancer Research Abstracts Immunology Abstracts
DatabaseTitleList	AIDS and Cancer Research Abstracts MEDLINE MEDLINE - Academic
Database_xml	– sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database
DeliveryMethod	fulltext_linktorsrc
Discipline	Medicine
EISSN	1521-7035
EndPage	88
ExternalDocumentID	PMC3444569 22940635 10_1016_j_clim_2012_07_015 S1521661612001908 1_s2_0_S1521661612001908
Genre	Review Research Support, Non-U.S. Gov't Journal Article Research Support, N.I.H., Extramural
GrantInformation_xml	– fundername: NIAMS NIH HHS grantid: R01 AR049449 – fundername: NIMHD NIH HHS grantid: R01 MD017579 – fundername: NIDCR NIH HHS grantid: R01 DE017570 – fundername: NIAMS NIH HHS grantid: R01 AR047988 – fundername: NIAMS NIH HHS grantid: R01 AR051203 – fundername: National Institute of Arthritis and Musculoskeletal and Skin Diseases : NIAMS grantid: R01 AR049449 \|\| AR – fundername: National Institute of Arthritis and Musculoskeletal and Skin Diseases : NIAMS grantid: R01 AR047988 \|\| AR
GroupedDBID	--- --K --M .1- .55 .FO .GJ .~1 0R~ 1B1 1P~ 1RT 1~. 1~5 29B 4.4 457 4G. 53G 5GY 5RE 5VS 6J9 7-5 71M 8P~ AAAJQ AAEDT AAEDW AAIKJ AAKOC AALRI AAOAW AAQFI AAQXK AARKO AATTM AAXKI AAXUO AAYWO ABBQC ABFNM ABFRF ABJNI ABMAC ABMZM ABPPZ ABXDB ACDAQ ACGFO ACGFS ACIEU ACRLP ACRPL ACVFH ADBBV ADCNI ADEZE ADFGL ADMUD ADNMO ADVLN AEBSH AEFWE AEIPS AEKER AENEX AEUPX AEVXI AFFNX AFJKZ AFPUW AFRHN AFTJW AFXIZ AGCQF AGEKW AGHFR AGQPQ AGUBO AGYEJ AIEXJ AIGII AIIUN AIKHN AITUG AJRQY AJUYK AKBMS AKRWK AKYEP ALMA_UNASSIGNED_HOLDINGS AMRAJ ANKPU ANZVX APXCP ASPBG AVWKF AXJTR AZFZN BKOJK BLXMC BNPGV CAG CJTIS COF CS3 DM4 DU5 EBS EFBJH EFKBS EJD EO8 EO9 EP2 EP3 F5P FDB FEDTE FGOYB FIRID FNPLU FYGXN G-Q GBLVA HVGLF HX~ HZ~ IH2 IHE J1W K-O KOM L7B LG5 LUGTX M41 MO0 N9A O-L O9- O9~ OAUVE OK0 OZT P-8 P-9 P2P PC. Q38 R2- ROL RPZ SDF SDG SDP SES SEW SPCBC SSH SSZ T5K X7M XPP Y6R Z5R ZGI ZMT ~G- AACTN AFCTW AFKWA AJOXV AMFUW RIG SSI AAIAV ABLVK ABYKQ AHPSJ AJBFU EFLBG LCYCR ZA5 AAYXX AGRNS CITATION CGR CUY CVF ECM EIF NPM 7X8 7T5 H94 5PM
ID	FETCH-LOGICAL-c616t-3417dc5d1049cff8275fbbc00c5b54c2ee92084a56900cdae26b2f955bdbfe673
IEDL.DBID	.~1
ISSN	1521-6616 1521-7035
IngestDate	Thu Aug 21 18:45:59 EDT 2025 Thu Jul 10 20:47:22 EDT 2025 Fri Jul 11 06:32:53 EDT 2025 Thu Apr 03 07:03:33 EDT 2025 Thu Apr 24 22:56:13 EDT 2025 Tue Jul 01 02:43:59 EDT 2025 Fri Feb 23 02:15:15 EST 2024 Sun Feb 23 10:19:49 EST 2025 Tue Aug 26 17:09:47 EDT 2025
IsPeerReviewed	true
IsScholarly	true
Issue	1
Keywords	Inflammation Scurfy mice Autoimmune diseases MOI Treg Multi-organ inflammation
Language	English
License	https://www.elsevier.com/tdm/userlicense/1.0 Copyright © 2012 Elsevier Inc. All rights reserved.
LinkModel	DirectLink
MergedId	FETCHMERGED-LOGICAL-c616t-3417dc5d1049cff8275fbbc00c5b54c2ee92084a56900cdae26b2f955bdbfe673
Notes	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 ObjectType-Review-3 content type line 23 ObjectType-Article-2 ObjectType-Feature-1
PMID	22940635
PQID	1041002256
PQPubID	23479
PageCount	7
ParticipantIDs	pubmedcentral_primary_oai_pubmedcentral_nih_gov_3444569 proquest_miscellaneous_1093467092 proquest_miscellaneous_1041002256 pubmed_primary_22940635 crossref_citationtrail_10_1016_j_clim_2012_07_015 crossref_primary_10_1016_j_clim_2012_07_015 elsevier_sciencedirect_doi_10_1016_j_clim_2012_07_015 elsevier_clinicalkeyesjournals_1_s2_0_S1521661612001908 elsevier_clinicalkey_doi_10_1016_j_clim_2012_07_015
ProviderPackageCode	CITATION AAYXX
PublicationCentury	2000
PublicationDate	2012-10-01
PublicationDateYYYYMMDD	2012-10-01
PublicationDate_xml	– month: 10 year: 2012 text: 2012-10-01 day: 01
PublicationDecade	2010
PublicationPlace	United States
PublicationPlace_xml	– name: United States
PublicationTitle	Clinical immunology (Orlando, Fla.)
PublicationTitleAlternate	Clin Immunol
PublicationYear	2012
Publisher	Elsevier Inc
Publisher_xml	– name: Elsevier Inc
References	Sadlack, Merz, Schorle, Schimpl, Feller, Horak (bb0010) 1993; 75 Vang, Yang, Mahmud, Burchill, Vegoe, Farrar (bb0025) 2008; 181 Imai, Hieshima, Haskell, Baba, Nagira, Nishimura, Kakizaki, Takagi, Nomiyama, Schall, Yoshie (bb0095) 1997; 91 Mach, Sauty, Iarossi, Sukhova, Neote, Libby, Luster (bb0075) 1999; 104 Sharma, Sung, Gaskin, Fu, Ju (bb0035) 2012; 38 Sadlack, Löhler, Schorle, Klebb, Haber, Sickel, Noelle, Horak (bb0015) 1995; 25 Howard, Paul (bb0070) 1982; 1 Cole, Strick, Paradis, Ogborne, Loetscher, Gladue, Lin, Boyd, Moser, Wood, Sahagan, Neote (bb0080) 1998; 187 Brunkow, Jeffery, Hjerrild, Paeper, Clark, Yasayko, Wilkinson, Galas, Ziegler, Ramsdell (bb0040) 2001; 27 Zheng, Sharma, Gaskin, Fu, Ju (bb0020) 2007; 179 Sharma, Sharma, Kim, Leitinger, Lee, Fu, Ju (bb0030) 2011; 186 Cote-Sierra, Foucras, Guo, Chiodetti, Young, Hu-Li, Zhu, Paul (bb0060) 2004; 101 Duroudier, Tulah, Sayers (bb0090) 2009; 64 Wildin, Ramsdell, Peake, Faravelli, Casanova, Buist, Levy-Lahad, Mazzella, Goulet, Perroni, Bricarelli, Byrne, McEuen, Proll, Appleby, Brunkow (bb0045) 2001; 27 Lin, Truong, Grossman, Haribhai, Williams, Wang, Martin, Chatila (bb0050) 2005; 116 Nanki, Lipsky (bb0055) 2000; 12 Mosmann, Cherwinski, Bond, Giedlin, Coffman (bb0065) 1986; 136 Rivas, Koh, Chen, Nguyen, Lee, Lawson, Chatila (bb0085) 2012; 122 Sharma, Fu, Ju (bb0005) 2011; 36 Cote-Sierra (10.1016/j.clim.2012.07.015_bb0060) 2004; 101 Lin (10.1016/j.clim.2012.07.015_bb0050) 2005; 116 Vang (10.1016/j.clim.2012.07.015_bb0025) 2008; 181 Mach (10.1016/j.clim.2012.07.015_bb0075) 1999; 104 Sharma (10.1016/j.clim.2012.07.015_bb0035) 2012; 38 Sadlack (10.1016/j.clim.2012.07.015_bb0015) 1995; 25 Sadlack (10.1016/j.clim.2012.07.015_bb0010) 1993; 75 Rivas (10.1016/j.clim.2012.07.015_bb0085) 2012; 122 Brunkow (10.1016/j.clim.2012.07.015_bb0040) 2001; 27 Sharma (10.1016/j.clim.2012.07.015_bb0005) 2011; 36 Duroudier (10.1016/j.clim.2012.07.015_bb0090) 2009; 64 Howard (10.1016/j.clim.2012.07.015_bb0070) 1982; 1 Mosmann (10.1016/j.clim.2012.07.015_bb0065) 1986; 136 Nanki (10.1016/j.clim.2012.07.015_bb0055) 2000; 12 Cole (10.1016/j.clim.2012.07.015_bb0080) 1998; 187 Imai (10.1016/j.clim.2012.07.015_bb0095) 1997; 91 Sharma (10.1016/j.clim.2012.07.015_bb0030) 2011; 186 Zheng (10.1016/j.clim.2012.07.015_bb0020) 2007; 179 Wildin (10.1016/j.clim.2012.07.015_bb0045) 2001; 27
References_xml	– volume: 122 start-page: 1933 year: 2012 end-page: 1947 ident: bb0085 article-title: MyD88 is critically involved in immune tolerance breakdown at environmental interfaces of Foxp3-deficient mice publication-title: J. Clin. Invest. – volume: 136 start-page: 2348 year: 1986 end-page: 2357 ident: bb0065 article-title: Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins publication-title: J. Immunol. – volume: 181 start-page: 3285 year: 2008 end-page: 3290 ident: bb0025 article-title: IL-2, ‐7, and ‐15, but not thymic stromal lymphopoeitin, redundantly govern CD4+Foxp3 publication-title: J. Immunol. – volume: 101 start-page: 3880 year: 2004 end-page: 3885 ident: bb0060 article-title: Interleukin 2 plays a central role in Th2 differentiation publication-title: Proc. Natl. Acad. Sci. U. S. A. – volume: 186 start-page: 1268 year: 2011 end-page: 1278 ident: bb0030 article-title: IL-2-controlled expression of multiple T cell trafficking genes and Th2 cytokines in the regulatory T cell-deficient Scurfy mice: implication to multiorgan inflammation and control of skin and lung inflammation publication-title: J. Immunol. – volume: 12 start-page: 1659 year: 2000 end-page: 1667 ident: bb0055 article-title: Lack of correlation between chemokine receptor and T(h)1/T(h)2 cytokine expression by individual memory T cells publication-title: Int. Immunol. – volume: 27 start-page: 18 year: 2001 end-page: 20 ident: bb0045 article-title: X-linked neonatal diabetes mellitus, enteropathy and endocrinopathy syndrome is the human equivalent of mouse scurfy publication-title: Nat. Genet. – volume: 104 start-page: 1041 year: 1999 end-page: 1050 ident: bb0075 article-title: Differential expression of three T lymphocyte-activating CXC chemokines by human atheroma-associated cells publication-title: J. Clin. Invest. – volume: 116 start-page: 1106 year: 2005 end-page: 1115 ident: bb0050 article-title: Allergic dysregulation and hyperimmunoglobulinemia E in Foxp3 mutant mice publication-title: J. Allergy Clin. Immunol. – volume: 179 start-page: 8035 year: 2007 end-page: 8041 ident: bb0020 article-title: A novel role of IL-2 in organ-specific autoimmune inflammation beyond regulatory T cell checkpoint: Both IL-2 Knockout and Fas mutation prolong lifespan of Scurfy mice but by different mechanisms publication-title: J. Immunol. – volume: 1 start-page: 1 year: 1982 end-page: 4 ident: bb0070 article-title: Interleukins for B lymphocytes publication-title: Lymphokine Res. – volume: 27 start-page: 68 year: 2001 end-page: 73 ident: bb0040 article-title: Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse publication-title: Nat. Genet. – volume: 75 start-page: 253 year: 1993 end-page: 261 ident: bb0010 article-title: Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene publication-title: Cell – volume: 36 start-page: 91 year: 2011 end-page: 97 ident: bb0005 article-title: IL-2: a two-faced master regulator of autoimmunity publication-title: J. Autoimmun. – volume: 91 start-page: 521 year: 1997 end-page: 530 ident: bb0095 article-title: Identification and molecular characterization of fractalkine receptor CX3CR1, which mediates both leukocyte migration and adhesion publication-title: Cell – volume: 25 start-page: 3053 year: 1995 end-page: 3059 ident: bb0015 article-title: Generalized autoimmune disease in interleukin-2-deficient mice is triggered by an uncontrolled activation and proliferation of CD4 publication-title: Eur. J. Immunol. – volume: 38 start-page: 322 year: 2012 end-page: 331 ident: bb0035 article-title: A novel function of IL-2: chemokine/chemoattractant/retention receptor genes induction in Th subsets for skin and lung inflammation publication-title: J. Autoimmun. – volume: 64 start-page: 823 year: 2009 end-page: 839 ident: bb0090 article-title: Leukotriene pathway genetics and pharmacogenetics in allergy publication-title: Allergy – volume: 187 start-page: 2009 year: 1998 end-page: 2021 ident: bb0080 article-title: Interferon-inducible T cell alpha chemoattractant (I-TAC): a novel non-ELR CXC chemokine with potent activity on activated T cells through selective high affinity binding to CXCR3 publication-title: J. Exp. Med. – volume: 186 start-page: 1268 year: 2011 ident: 10.1016/j.clim.2012.07.015_bb0030 article-title: IL-2-controlled expression of multiple T cell trafficking genes and Th2 cytokines in the regulatory T cell-deficient Scurfy mice: implication to multiorgan inflammation and control of skin and lung inflammation publication-title: J. Immunol. doi: 10.4049/jimmunol.1002677 – volume: 1 start-page: 1 year: 1982 ident: 10.1016/j.clim.2012.07.015_bb0070 article-title: Interleukins for B lymphocytes publication-title: Lymphokine Res. – volume: 179 start-page: 8035 year: 2007 ident: 10.1016/j.clim.2012.07.015_bb0020 article-title: A novel role of IL-2 in organ-specific autoimmune inflammation beyond regulatory T cell checkpoint: Both IL-2 Knockout and Fas mutation prolong lifespan of Scurfy mice but by different mechanisms publication-title: J. Immunol. doi: 10.4049/jimmunol.179.12.8035 – volume: 27 start-page: 18 year: 2001 ident: 10.1016/j.clim.2012.07.015_bb0045 article-title: X-linked neonatal diabetes mellitus, enteropathy and endocrinopathy syndrome is the human equivalent of mouse scurfy publication-title: Nat. Genet. doi: 10.1038/83707 – volume: 64 start-page: 823 year: 2009 ident: 10.1016/j.clim.2012.07.015_bb0090 article-title: Leukotriene pathway genetics and pharmacogenetics in allergy publication-title: Allergy doi: 10.1111/j.1398-9995.2009.02015.x – volume: 116 start-page: 1106 year: 2005 ident: 10.1016/j.clim.2012.07.015_bb0050 article-title: Allergic dysregulation and hyperimmunoglobulinemia E in Foxp3 mutant mice publication-title: J. Allergy Clin. Immunol. doi: 10.1016/j.jaci.2005.08.046 – volume: 104 start-page: 1041 year: 1999 ident: 10.1016/j.clim.2012.07.015_bb0075 article-title: Differential expression of three T lymphocyte-activating CXC chemokines by human atheroma-associated cells publication-title: J. Clin. Invest. doi: 10.1172/JCI6993 – volume: 36 start-page: 91 year: 2011 ident: 10.1016/j.clim.2012.07.015_bb0005 article-title: IL-2: a two-faced master regulator of autoimmunity publication-title: J. Autoimmun. doi: 10.1016/j.jaut.2011.01.001 – volume: 75 start-page: 253 year: 1993 ident: 10.1016/j.clim.2012.07.015_bb0010 article-title: Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene publication-title: Cell doi: 10.1016/0092-8674(93)80067-O – volume: 91 start-page: 521 year: 1997 ident: 10.1016/j.clim.2012.07.015_bb0095 article-title: Identification and molecular characterization of fractalkine receptor CX3CR1, which mediates both leukocyte migration and adhesion publication-title: Cell doi: 10.1016/S0092-8674(00)80438-9 – volume: 25 start-page: 3053 year: 1995 ident: 10.1016/j.clim.2012.07.015_bb0015 article-title: Generalized autoimmune disease in interleukin-2-deficient mice is triggered by an uncontrolled activation and proliferation of CD4+ T cells publication-title: Eur. J. Immunol. doi: 10.1002/eji.1830251111 – volume: 27 start-page: 68 year: 2001 ident: 10.1016/j.clim.2012.07.015_bb0040 article-title: Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse publication-title: Nat. Genet. doi: 10.1038/83784 – volume: 101 start-page: 3880 year: 2004 ident: 10.1016/j.clim.2012.07.015_bb0060 article-title: Interleukin 2 plays a central role in Th2 differentiation publication-title: Proc. Natl. Acad. Sci. U. S. A. doi: 10.1073/pnas.0400339101 – volume: 136 start-page: 2348 year: 1986 ident: 10.1016/j.clim.2012.07.015_bb0065 article-title: Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins publication-title: J. Immunol. doi: 10.4049/jimmunol.136.7.2348 – volume: 122 start-page: 1933 year: 2012 ident: 10.1016/j.clim.2012.07.015_bb0085 article-title: MyD88 is critically involved in immune tolerance breakdown at environmental interfaces of Foxp3-deficient mice publication-title: J. Clin. Invest. doi: 10.1172/JCI40591 – volume: 181 start-page: 3285 year: 2008 ident: 10.1016/j.clim.2012.07.015_bb0025 article-title: IL-2, ‐7, and ‐15, but not thymic stromal lymphopoeitin, redundantly govern CD4+Foxp3+ regulatory T cell development publication-title: J. Immunol. doi: 10.4049/jimmunol.181.5.3285 – volume: 12 start-page: 1659 year: 2000 ident: 10.1016/j.clim.2012.07.015_bb0055 article-title: Lack of correlation between chemokine receptor and T(h)1/T(h)2 cytokine expression by individual memory T cells publication-title: Int. Immunol. doi: 10.1093/intimm/12.12.1659 – volume: 187 start-page: 2009 year: 1998 ident: 10.1016/j.clim.2012.07.015_bb0080 article-title: Interferon-inducible T cell alpha chemoattractant (I-TAC): a novel non-ELR CXC chemokine with potent activity on activated T cells through selective high affinity binding to CXCR3 publication-title: J. Exp. Med. doi: 10.1084/jem.187.12.2009 – volume: 38 start-page: 322 year: 2012 ident: 10.1016/j.clim.2012.07.015_bb0035 article-title: A novel function of IL-2: chemokine/chemoattractant/retention receptor genes induction in Th subsets for skin and lung inflammation publication-title: J. Autoimmun. doi: 10.1016/j.jaut.2012.02.001
SSID	ssj0005226
Score	2.1387815
SecondaryResourceType	review_article
Snippet	Both Il2−/− mice and Scurfy (Sf) mutant mice that are deficient in FoxP3, develop multi-organ inflammation but only the latter display severe skin and lung... Abstract Both Il2 −/− mice and Scurfy (Sf) mutant mice that are deficient in FoxP3, develop multi-organ inflammation but only the latter display severe skin... Both Il2(-/-) mice and Scurfy (Sf) mutant mice that are deficient in FoxP3, develop multi-organ inflammation but only the latter display severe skin and lung... Both Il2-/-mice and Scurfy (Sf) mutant mice that are deficient in FoxP3, develop multi-organ inflammation but only the latter display severe skin and lung... Both Il2 −/− mice and Scurfy (Sf) mutant mice that are deficient in FoxP3, develop multi-organ inflammation but only the latter display severe skin and lung...
SourceID	pubmedcentral proquest pubmed crossref elsevier
SourceType	Open Access Repository Aggregation Database Index Database Enrichment Source Publisher
StartPage	82
SubjectTerms	Allergy and Immunology Animals Autoimmune diseases CD4 antigen CD4 Antigens - genetics CD4 Antigens - immunology Cell Movement - genetics Cell Movement - immunology Cytokines - biosynthesis Cytokines - immunology Foxp3 protein Gene expression Gene Expression - immunology Helper cells Inflammation Inflammatory diseases Interleukin 2 Interleukin-2 - genetics Interleukin-2 - immunology Lung Lung - immunology Lung - pathology Lymphocyte Activation - genetics Lymphocyte Activation - immunology Lymphocytes T Mice Mice, Knockout Migration Pneumonia - genetics Pneumonia - immunology Pneumonia - pathology Protein transport Receptors, Cell Surface - genetics Receptors, Cell Surface - immunology Reviews Scurfy mice Skin Skin - immunology Skin - pathology Skin diseases Th1 Cells - immunology Th1 Cells - pathology Th2 Cells - immunology Th2 Cells - pathology Treg
Title	IL-2 controls trafficking receptor gene expression and Th2 response for skin and lung inflammation
URI	https://www.clinicalkey.com/#!/content/1-s2.0-S1521661612001908 https://www.clinicalkey.es/playcontent/1-s2.0-S1521661612001908 https://dx.doi.org/10.1016/j.clim.2012.07.015 https://www.ncbi.nlm.nih.gov/pubmed/22940635 https://www.proquest.com/docview/1041002256 https://www.proquest.com/docview/1093467092 https://pubmed.ncbi.nlm.nih.gov/PMC3444569
Volume	145
hasFullText	1
inHoldings	1
isFullTextHit
isPrint
link	http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1LaxsxEB5CCqWX0nfdR1Cht7KxrJVW3mMIDU7b5NIEchN6EhezMV0Hespvz8yu1sRNcKFHe2e8lubTzKfdmRHA5xRsqW1ECwQ-LSSiorAVEjln0Rt6Vem-XdPJaTU7l98u1MUOHA61MJRWmX1_79M7b52_GefZHC_n8_FPijwYXTBEE0_pCn6l1ITy_Zu7aR7dkWskXJB0Lpzpc7z8Yk7V6PQ8UO9zOhr34eB0n3z-nUN5JygdPYOnmU2yg_4PP4ed2LyAxyf5fflLcMc_CsFyOnrL8CeoYwQ9HWc46rjEDTdDBEUW_-SE2IbZJrCzS4ECXfZsZEhrWYs63ZUFOgeGqEQg9UWPr-D86OvZ4azIpyoUHoe_KjBs6eBVwH1Y7VOaCq2Sc55zr5ySXsRYCz6VVuG-mftgo6icSLVSLrgUK12-ht3mqolvgVGdkAq6QtqWZD3xlicvhQthMo2lTXYEk2E6jc8tx-nki4UZcst-GTKBIRMYrg2aYARf1jrLvuHGVulysJIZSknR-RmMB1u19ENasc3rtzUT06KwuYexEai15gZM_3nHTwOEDK5feiljm3h1jXfikrrgIvPcJlOXkhrtiRG86WG3nhshauRkJY1pA5BrAeofvnmlmV92fcRLKZE-1-_-c0zv4Ql96jMbP8Du6vd1_IgMbeX2uiW4B48Ojr_PTm8B0Qk7oQ
linkProvider	Elsevier
linkToHtml	http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1LbxMxELZKkYAL4llSXkaCE9rG8drr3QMHBFQJTXohlXozfq0aFG0jNlXhwp_iDzKz640aWgUJqde1Zx8z42_G3nkQ8rr0JlUmgAQ8yxMBWpGYDBw5awANncxUW65pcpgNj8TnY3m8RX53uTAYVhmxv8X0Bq3jlX7kZn8xm_W_oOUB6wImGv0UlsfIyoPw8xz2bfW70UcQ8hvO9z9NPwyT2FogcUCxTAC7lXfSw2akcGWZcyVLax1jTlopHA-h4CwXRsLmkTlvAs8sLwsprbdlyFQK971BbgqAC2ybsPfrYlxJ0-MN3y7B14uZOm1QmZvPMP0dDyDVHsNevFdbw8ve7t9Bmxes4P49cje6r_R9y6H7ZCtUD8itSfxB_5DY0TjhNMa_1xRugSUq8DieApvDAnb4FFQ20PAjRuBW1FSeTk84TGjCdQMFP5rWQNOMzAGNKCwD0Nw2y_IROboWXj8m29VpFZ4QiolJ0qsM_MRSFANnWOkEt94P8pCa0vTIoGOndrHGObbamOsumO2bRhFoFIFmSoMIeuTtimbRVvjYODvtpKS73FVAWw0GaCOVuooq1BEwaj3QNUzWl5S6R-SKcm1d_POJrzoV0gAY-BfIVOH0DJ7EBJbdBVd305wiFVjZj_fITqt2K95wXoATmOI3rSnkagIWLF8fqWYnTeHyVAjw14vd__yml-T2cDoZ6_Ho8OApuYMjbVjlM7K9_H4WnoN7uLQvmuVIydfrXv9_AII6eB0
openUrl	ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=IL-2+controls+trafficking+receptor+gene+expression+and+Th2+response+for+skin+and+lung+inflammation&rft.jtitle=Clinical+immunology+%28Orlando%2C+Fla.%29&rft.au=Ju%2C+Shyr-Te&rft.au=Sharma%2C+Rahul&rft.au=Gaskin%2C+Felicia&rft.au=Fu%2C+Shu+Man&rft.date=2012-10-01&rft.issn=1521-7035&rft.eissn=1521-7035&rft.volume=145&rft.issue=1&rft.spage=82&rft_id=info:doi/10.1016%2Fj.clim.2012.07.015&rft.externalDBID=NO_FULL_TEXT
thumbnail_m	http://utb.summon.serialssolutions.com/2.0.0/image/custom?url=https%3A%2F%2Fcdn.clinicalkey.com%2Fck-thumbnails%2F15216616%2FS1521661612X0010X%2Fcov150h.gif