Isoflavones and Prostate Cancer： A Review of Some Critical Issues

• Published in: Chinese medical journal Vol. 129; no. 3; pp. 341 - 347
• Main Authors: Zhang, Hong-Yi, Cui, Jie, Zhang, Ye, Wang, Zhen-Long, Chong, Tie, Wang, Zi-Ming
• Format: Journal Article
• Language: English
• Published: China Wolters Kluwer - Medknow Publications 05.02.2016; Medknow Publications and Media Pvt. Ltd; Lippincott Williams & Wilkins Ovid Technologies; Department of Urology, Yan'an University Affiliated Hospital, Yan'an, Shaanxi 716000, China%Department of Oncology, Yan'an University Affiliated Hospital, Yan'an, Shaanxi 716000, China%Department of Urology, Yan'an University Affiliated Hospital, Yan'an, Shaanxi 716000, China%Department of Urology, Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710004, China; Department of Urology, Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710004, China; Medknow Publications & Media Pvt Ltd; Wolters Kluwer
• Subjects: Androgens; Cancer prevention; Care and treatment; Estrogens; Health aspects; Humans; Isoflavone; Phytoestrogen; Prostate Cancer; Isoflavones; Isoflavones - therapeutic use; Male; PCA; Phytoestrogens - therapeutic use; Prevention; Prostate cancer; Prostatic Neoplasms - prevention & control; PubMed; Review; Soy products; 保护作用; 前列腺癌; 大豆异黄酮; 数据来源; 染料木苷; 植物雌激素; China; United States > US; Japan; Isoflavone; Phytoestrogen; Prostate Cancer
• ISSN: 0366-6999; 2542-5641
• DOI: 10.4103/0366-6999.174488

Objective： The purpose of this review is to discuss some critical issues of isoflavones protective against the development of prostate cancer （PCa）.Data Sources： Data cited in this review were obtained primarily from PubMed and Embase from 1975 to 2015.Study Selection： Articles were selected with the search terms ＆quot;isoflavone＆quot;, ＆quot;Phytoestrogen＆quot;, ＆quot;soy＆quot;, ＆quot;genistin＆quot;, and ＆quot;PCa＆quot;.Results： Isoflavones do not play an important role on prostate-specific antigen levels reduction in PCa patients or healthy men.The effect ofisoflavones on sex hormone levels and PCa risk may be determined by equol converting bacteria in the intestine, specific polymorphic variation and concentrations of isoflavones.The intake of various types of phytoestrogens with lower concentrations in the daily diet may produce synergistic effects against PCa.Moreover, prostate tissue may concentrate isoflavones to potentially anti-carcinogenic levels.In addition, it is noteworthy that isoflavones may act as an agonist in PCa.Conclusions： Isoflavones play a protective role against the development of PCa.However, careful consideration should be given when isoflavones are used in the prevention and treatment of PCa.