哺乳动物雷帕霉素靶蛋白信号通路上的miRNA调控

哺乳动物雷帕霉素靶蛋白（the mammalian target of rapamycin,mTOR）信号通路在细胞增殖、凋亡、细胞周期进程和代谢中发挥重要作用。人类肿瘤中常常发生mTOR信号通路的异常,使得mTOR通路成为抗肿瘤治疗的主要靶点。近年来研究发现miRNA（微小RNA,microRNA）参与多种生物学过程的调控。miRNA可以通过直接或间接作用调控mTOR通路,使得mTOR信号也成为miRNA抗肿瘤治疗的潜在靶点。...

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Bibliographic Details
Published in复旦学报（医学版） Vol. 43; no. 5; pp. 603 - 609
Main Author 张瑾 金波 施海明
Format Journal Article
LanguageChinese
Published 复旦大学附属华山医院心内科 上海200040 2016
Subjects
miRNA
mTOR信号通路
抗肿瘤治疗
anti-tumor therapy
miRNA
mTOR signal pathway
抗肿瘤治疗
mTOR信号通路
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Summary:哺乳动物雷帕霉素靶蛋白（the mammalian target of rapamycin,mTOR）信号通路在细胞增殖、凋亡、细胞周期进程和代谢中发挥重要作用。人类肿瘤中常常发生mTOR信号通路的异常,使得mTOR通路成为抗肿瘤治疗的主要靶点。近年来研究发现miRNA（微小RNA,microRNA）参与多种生物学过程的调控。miRNA可以通过直接或间接作用调控mTOR通路,使得mTOR信号也成为miRNA抗肿瘤治疗的潜在靶点。
Bibliography:ZHANG Jin, JIN Bo, SHI Hai-ming （Department of Cardiology, Huashan Hospital, Fudan University, Shanghai 200040, China）
mTOR signal pathway; miRNA; anti-tumor therapy
The mammalian target of rapamycin（mTOR）signal pathway is a key intracellular signal transduction pathway,which plays important roles in cell proliferation,apoptosis,cell cycle and metabolism.Dysregulation of mTOR signalling often occurs in a variety of human malignant diseases,making it a crucial and validated target in the treatment of cancer.More recently,microRNAs are involved in modulation of a wide range of biological processes and human diseases.Evidence collected to date shows that microRNA regulate mTOR pathway through direct and indirect interactions.The mTOR pathway is a promising target by miRNAs for therapy.
31-1885/R
ISSN:1672-8467
DOI:10.3969/j.issn.1672-8467.2016.05.016