驻春胶囊治疗糖尿病性骨质疏松患者的40例临床观察

目的观察驻春胶囊治疗糖尿病性骨质疏松症的临床疗效。方法将2009-2016年在河南省洛阳正骨医院就诊80例2型糖尿病性骨质疏松症患者（5年以上糖尿病病史）随机分为驻春胶囊治疗组40例和阿仑膦酸钠对照组40例,两组患者首先均予以控制血糖,在继续原有降糖药治疗的基础上,驻春胶囊治疗组患者服用驻春胶囊（医院老中医经验协定方内部制剂）,每日早晚各服一次,每次5粒。阿仑膦酸钠对照组患者服用阿仑膦酸钠,每周一次,每次70 mg。每3个月为一个疗程,连续服用两个疗程后观察临床疗效。患者分别在治疗前后检测骨密度值,血清钙（Ca）、骨钙素（bone glaprotein,BGP）和抗酒石酸酸性磷酸酶5b（tar...

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Published in中国骨质疏松杂志 Vol. 24; no. 2; pp. 214 - 217
Main Author 李跃京;韩松辉;刘锋卫;孔凡国;李彦州;赵敏
Format Journal Article
LanguageChinese
Published 河南省洛阳正骨医院(河南省骨科医院),河南 洛阳,471000 2018
Subjects
驻春胶囊;糖尿病;2型;骨质疏松;骨密度;血清钙;血清磷;骨钙素
骨质疏松
Bone glaprotein
糖尿病,2型
P
Diabetes mellitus,type 2
Osteoporosis
驻春胶囊
骨密度
骨钙素
血清钙
Zhuchun capsule
Bone mineral density
Ca
血清磷
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Summary:目的观察驻春胶囊治疗糖尿病性骨质疏松症的临床疗效。方法将2009-2016年在河南省洛阳正骨医院就诊80例2型糖尿病性骨质疏松症患者（5年以上糖尿病病史）随机分为驻春胶囊治疗组40例和阿仑膦酸钠对照组40例,两组患者首先均予以控制血糖,在继续原有降糖药治疗的基础上,驻春胶囊治疗组患者服用驻春胶囊（医院老中医经验协定方内部制剂）,每日早晚各服一次,每次5粒。阿仑膦酸钠对照组患者服用阿仑膦酸钠,每周一次,每次70 mg。每3个月为一个疗程,连续服用两个疗程后观察临床疗效。患者分别在治疗前后检测骨密度值,血清钙（Ca）、骨钙素（bone glaprotein,BGP）和抗酒石酸酸性磷酸酶5b（tartra-resistant acid phosphatase 5b,TRACP-5b）的含量,同时评价其临床症状。结果驻春胶囊能明显提高患者骨密度,升高血清钙和BGP含量,降低血清TRACP-5b的含量,改善糖尿病性骨质疏松症临床症状,同时驻春胶囊在改善临床症状及BGP含量方面明显优于阿仑膦酸钠对照组。结论驻春胶囊对糖尿病性骨质疏松症患者有较好的临床疗效,其作用机理值得进一步研究。
Bibliography:LI Yuejing , HAN Songhui, LIU Fengwei, KONG Fanguo, LI Yanzhou, ZHAO Min Luoyang （Orthopedic Hospital of Henan Province （Orthopedic Hospital of Henan Province）, Luoyang, Henan 471000, China）
11-3701/R
Objective To observe the clinical efficacy of Zhuchun capsule in treating osteoporosis in patients with type 2 diabetes.Methods 80 cases of osteoporotic patients with type 2 diabetes were randomly divided into two groups,namely,Zhuchun capsule treatment group（ n = 40） and alendronate sodium control group（ n = 40）. Patients in the Chinese medicine treatment group was administrated with Zhuchun capsule,5 capsules twice daily,while patients in the alendronate sodium control group were administrated with alendronate sodium,70 mg once per week. Both treatments lasted for two courses（ 3 months/course）. Bone mineral density（ BMD） as well as serum levels of Ca,P,bone glutamic acid protein（ BGP）,and tartrate-resistant acid phosphatase 5 b（ TRAP-5 b） were determined before and after treatment. Results Administration of Zhuc
ISSN:1006-7108
DOI:10.3969/j.issn.1006-7108.2018.02.015