Prognostic impact of the 2016 WHO classification of diffuse gliomas in the French POLA cohort

• Published in: Acta neuropathologica Vol. 132; no. 4; pp. 625 - 634
• Main Authors: Tabouret, Emeline, Nguyen, Anh Tuan, Dehais, Caroline, Carpentier, Catherine, Ducray, François, Idbaih, Ahmed, Mokhtari, Karima, Jouvet, Anne, Uro-Coste, Emmanuelle, Colin, Carole, Chinot, Olivier, Loiseau, Hugues, Moyal, Elisabeth, Maurage, Claude-Alain, Polivka, Marc, Lechapt-Zalcman, Emmanuèle, Desenclos, Christine, Meyronet, David, Delattre, Jean-Yves, Figarella-Branger, Dominique
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.10.2016; Springer; Springer Nature B.V; Springer Verlag
• Subjects: Adolescent; Adult; Aged; Aged, 80 and over; Analysis; Astrocytoma - epidemiology; Astrocytoma - genetics; Brain cancer; Brain Neoplasms - epidemiology; Brain Neoplasms - genetics; Cancer; Cohort Studies; Diagnosis; Disease-Free Survival; Female; Glioma - classification; Glioma - epidemiology; Glioma - genetics; Gliomas; Humans; Life Sciences; Male; Medical prognosis; Medicine; Medicine & Public Health; Middle Aged; Mutation; Mutation - genetics; Neurobiology; Neurons and Cognition; Neurosciences; Oligodendroglioma - epidemiology; Oligodendroglioma - genetics; Original Paper; Pathology; Prognosis; Tumors; World Health Organization; Young Adult; France; Paris France; mutation; 2016 WHO classification; Diffuse glioma; 1p/19q codeletion; IDH1/2 mutation
• ISSN: 0001-6322; 1432-0533; 1432-0533
• DOI: 10.1007/s00401-016-1611-8

The new WHO classification of diffuse gliomas has been refined and now includes the 1p/19q codeletion, IDH1/2 mutation, and histone H3-K27M mutation. Our objective was to assess the prognostic value of the updated 2016 WHO classification in the French POLA cohort. All cases of high-grade oligodendroglial tumors sent for central pathological review and included into the French nationwide POLA cohort were reclassified according to the updated 4th WHO classification. In total, 1041 patients were included, with a median age at diagnosis of 50.4 years (range 17.1–84.4). Based on the new histomolecular classification, diagnoses included anaplastic oligodendroglioma IDH mutant and 1p/19q-codeleted (32.5 %), anaplastic astrocytoma IDH mutant ( IDH mut ) (11.0 %), anaplastic astrocytoma IDH wild type ( IDH wt ) (5.3 %), glioblastoma IDH mut (17.1 %), and glioblastoma IDH wt (33.2 %). Ten patients presented with a diffuse midline tumor, H3 K27M mutant. The new WHO classification was prognostic for progression-free survival (PFS) and overall survival (OS) ( p  < 0.001). We did not find prognosis differences between grades III and IV for IDH mut 1p/19q intact and IDH wt gliomas in univariate and multivariate analyses. Among anaplastic astrocytoma IDH wt , cases with chromosome arm 7p gain and 10q loss (55 %) had shorter PFS than the others ( p  = 0.027). In conclusion, the new WHO histomolecular classification of diffuse gliomas presented with high prognostic value. Grading was not discriminant between grade III and IV high-grade gliomas.