POSSIBLE INVOLVEMENT OF CYCLIC AMP IN INFLAMMATION INDUCED BY A SURFACTANT

Alkyldimethylbenzylammonium chloride (alkyl-DBAC), a cationic surfactant, produces acute exudative inflammation accompanied by an enhancement of energy metabolism. The mechanism of metabolic changes, consequently the cyclic AMP level and the effects of certain drugs were determined in the gastrocnem...

Full description

Saved in:
Bibliographic Details
Published inJapanese journal of pharmacology Vol. 27; no. 6; pp. 762 - 767
Main Author FUTAMI, Takahiro
Format Journal Article
LanguageEnglish
Published Japan The Japanese Pharmacological Society 01.01.1977
Subjects
Animals
Anti-Inflammatory Agents - pharmacology
Cyclic AMP - metabolism
Depression, Chemical
Exudates and Transudates
Histamine - pharmacology
Inflammation - chemically induced
Inflammation - metabolism
Male
Muscles - metabolism
Quaternary Ammonium Compounds
Rats
Surface-Active Agents
Online AccessGet full text

Cover

More Information
Summary:Alkyldimethylbenzylammonium chloride (alkyl-DBAC), a cationic surfactant, produces acute exudative inflammation accompanied by an enhancement of energy metabolism. The mechanism of metabolic changes, consequently the cyclic AMP level and the effects of certain drugs were determined in the gastrocnemius muscles of rats in which acute exudative inflammation had been induced by intramuscular injections of alkyl-DBAC. A transient increase in the cyclic AMP level was noted at 15 to 30 minutes after the injection of alkyl-DBAC, and this elevation was antagonized by chlorpromazine, diphenhydramine, promethazine, aspirin and indomethacin. The time course of increasing tendency in the cyclic AMP level after the injection of histamine closely paralleled that of alkyl-DBAC. These results suggest that cyclic AMP may be involved in the metabolic changes with inflammation induced by alkyl-DBAC.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0021-5198
1347-3506
DOI:10.1254/jjp.27.763