5-HT1A-Receptor Subtype Mediates the Effect of Fluvoxamine, a Selective Serotonin Reuptake Inhibitor, on Marble-Burying Behavior in Mice

• Published in: Japanese journal of pharmacology Vol. 68; no. 1; pp. 65 - 70
• Main Authors: Ichimaru, Yasuyuki, Egawa, Takashi, Sawa, Aiko
• Format: Journal Article
• Language: English
• Published: Kyoto The Japanese Pharmacological Society 1995; Japanese Pharmacological Society
• Subjects: Analysis of Variance; Animals; Anti-Anxiety Agents - pharmacology; Antidepressive Agents - pharmacology; Behavior, Animal - drug effects; Biological and medical sciences; Disease Models, Animal; Dose-Response Relationship, Drug; Fluvoxamine; Fluvoxamine - pharmacology; Male; Marble-burying; Medical sciences; Mice; Mice, Inbred ICR; Neuropharmacology; Obsessive compulsive disorder; Pharmacology. Drug treatments; Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease); Psychology. Psychoanalysis. Psychiatry; Psychopharmacology; Receptors, Serotonin - metabolism; Receptors, Serotonin, 5-HT1; Selective serotonin reuptake inhibitor; Time Factors; Obsessive compulsive disorder; Marble-burying; Fluvoxamine; Selective serotonin reuptake inhibitor; Psychotropic; Rodentia; Oral administration; Vertebrata; Chemotherapy; Mammalia; Treatment; Mouse; Animal; Antidepressant agent; Anxiety; Mechanism of action; 5-HT1A receptor

The effect of fluvoxamine, a selective serotonin (5-HT) reuptake inhibitor, was studied in a model of anxiety and/or obsessive compulsive disorder (OCD) in mice. In the anxiety/OCD model, marble-burying behavior, marble-burying was significantly suppressed by fluvoxamine at 30 and 60 mg/kg, p.o. and...