5-HT1A-Receptor Subtype Mediates the Effect of Fluvoxamine, a Selective Serotonin Reuptake Inhibitor, on Marble-Burying Behavior in Mice

• Published in: Japanese journal of pharmacology Vol. 68; no. 1; pp. 65 - 70
• Main Authors: Ichimaru, Yasuyuki, Egawa, Takashi, Sawa, Aiko
• Format: Journal Article
• Language: English
• Published: Kyoto The Japanese Pharmacological Society 1995; Japanese Pharmacological Society
• Subjects: Analysis of Variance; Animals; Anti-Anxiety Agents - pharmacology; Antidepressive Agents - pharmacology; Behavior, Animal - drug effects; Biological and medical sciences; Disease Models, Animal; Dose-Response Relationship, Drug; Fluvoxamine; Fluvoxamine - pharmacology; Male; Marble-burying; Medical sciences; Mice; Mice, Inbred ICR; Neuropharmacology; Obsessive compulsive disorder; Pharmacology. Drug treatments; Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease); Psychology. Psychoanalysis. Psychiatry; Psychopharmacology; Receptors, Serotonin - metabolism; Receptors, Serotonin, 5-HT1; Selective serotonin reuptake inhibitor; Time Factors; Obsessive compulsive disorder; Marble-burying; Fluvoxamine; Selective serotonin reuptake inhibitor; Psychotropic; Rodentia; Oral administration; Vertebrata; Chemotherapy; Mammalia; Treatment; Mouse; Animal; Antidepressant agent; Anxiety; Mechanism of action; 5-HT1A receptor
• ISSN: 0021-5198; 1347-3506
• DOI: 10.1254/jjp.68.65

The effect of fluvoxamine, a selective serotonin (5-HT) reuptake inhibitor, was studied in a model of anxiety and/or obsessive compulsive disorder (OCD) in mice. In the anxiety/OCD model, marble-burying behavior, marble-burying was significantly suppressed by fluvoxamine at 30 and 60 mg/kg, p.o. and the monoamine reuptake inhibitor clomipramine, at 60 mg/kg, p.o. No suppressive effect, however, was observed by the selective norepinephrine reuptake inhibitor desipramine at doses from 15 to 60 mg/kg, p.o. Suppressive effects were obtained by the serotonergic anxiolytic buspirone at 30 and 60 mg/kg, p.o. and the benzodiazepine anxiolytic diazepam at 10 mg/kg, p.o. The effect of fluvoxamine on marble-burying was slightly attenuated after repeated administration. On the other hand, both the effects of buspirone and diazepam completely disappeared after repeated administration. Effect of fluvoxamine on the marble-burying was unaffected by the 5-HT2 antagonist ritanserin. However, the 5-HT1A antagonist NAN-190 (1-(2-methoxyphenyl)-4-[4-(2-phthalimido)butyl] piperazine) inhibited the suppressive effect of fluvoxamine on the marble-burying. From these results, the 5-HT1A-receptor subtype may be involved in the suppressive effect of fluvoxamine on the marble-burying, but the 5-HT2-receptor subtype is not involved in this effect.