Pathologically Confirmed Malignant Syphilis in an HIV-Infected Patient

We report a case of pathologically confirmed malignant syphilis in an HIV-infected patient. Physical examinations revealed ulceronecrotic skin lesions. Skin biopsies demonstrated syphilis spirochetes on immunohistochemical stain, and syphilis serological titers were positive. Treatment with intraven...

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Published inInternal Medicine Vol. 50; no. 20; pp. 2423 - 2426
Main Authors Yanagisawa, Naoki, Ando, Minoru, Imamura, Akifumi, Akagi, Kumiko, Horiguchi, Shin-ichiro, Suganuma, Akihiko, Ajisawa, Atsushi
Format Journal Article
LanguageEnglish
Published Japan The Japanese Society of Internal Medicine 01.01.2011
Subjects
Adult
HIV
HIV Infections - complications
Human immunodeficiency virus
Humans
Male
malignant syphilis
Spirochetes
Syphilis - complications
Syphilis - pathology
Treponema pallidum
ulceronodular skin lesions
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Summary:We report a case of pathologically confirmed malignant syphilis in an HIV-infected patient. Physical examinations revealed ulceronecrotic skin lesions. Skin biopsies demonstrated syphilis spirochetes on immunohistochemical stain, and syphilis serological titers were positive. Treatment with intravenous penicillin G was begun, and complete resolution of the skin lesions was observed. A rapid plasma reagin titer test performed 3 months after treatment revealed a 4-fold reduction in the titer, indicating successful treatment.
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ISSN:0918-2918
1349-7235
1349-7235
DOI:10.2169/internalmedicine.50.5605