The impact of autophagy in spermiogenesis

Autophagy is an evolutionarily .conserved self-digestion process whichis essential to keep basal homeostasis in a cell. During this process, degradation and recycling of many cytoplasmic components including the long-lived, unnecessary or aggregated proteins and damaged organelles is achieved throug...

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Bibliographic Details
Published inAsian journal of andrology Vol. 19; no. 6; pp. 617 - 618
Main Authors Ozturk, Nihan, Steger, Klaus, Schagdarsurengin, Undraga
Format Journal Article
LanguageEnglish
Published China Medknow Publications and Media Pvt. Ltd 01.11.2017
Medknow Publications & Media Pvt. Ltd
Medknow Publications & Media Pvt Ltd
Wolters Kluwer Medknow Publications
Subjects
Apoptosis
Autophagy
Biosynthesis
Cell differentiation
Cytoplasm
Cytoskeleton
Defects
Enzymes
Humans
Invited Research Highlight
Male
Motility
Proteins
Rodents
Sperm
Spermatids
Spermatogenesis
Spermatozoa
Studies
分子机制
基础稳定
消化过程
真核生物
精子发生
精子形成
细胞分化
自噬
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Summary:Autophagy is an evolutionarily .conserved self-digestion process whichis essential to keep basal homeostasis in a cell. During this process, degradation and recycling of many cytoplasmic components including the long-lived, unnecessary or aggregated proteins and damaged organelles is achieved through lysosomal machinery. Autophagy has a critical role for lower eukaryotic organisms such as yeast to survive and adapt to nutrient starvation conditions. In addition to this primary function, autophagy appears as a crucial mechanism for cell differentiation and development enabling the cells to modify their content and morphology in response to environmental and hormonal cues. A recent study by Shang et all shed more light on the molecular mechanisms of how autophagy regulates spermiogenesis.
Bibliography:Autophagy is an evolutionarily .conserved self-digestion process whichis essential to keep basal homeostasis in a cell. During this process, degradation and recycling of many cytoplasmic components including the long-lived, unnecessary or aggregated proteins and damaged organelles is achieved through lysosomal machinery. Autophagy has a critical role for lower eukaryotic organisms such as yeast to survive and adapt to nutrient starvation conditions. In addition to this primary function, autophagy appears as a crucial mechanism for cell differentiation and development enabling the cells to modify their content and morphology in response to environmental and hormonal cues. A recent study by Shang et all shed more light on the molecular mechanisms of how autophagy regulates spermiogenesis.
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ISSN:1008-682X
1745-7262
DOI:10.4103/1008-682X.190324