Mutation of MED12 is not a frequent occurrence in prostate cancer of Korean patients

Prostate cancer is one of the major health care problems, but the molecular pathogenesis has been relatively insufficiently elucidated. Recently, whole exome sequencing of prostate cancer identified recurrent mutations involving MED12 in Caucasian patients, which finding was not reproduced in one su...

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Published inAsian journal of andrology Vol. 19; no. 3; pp. 346 - 349
Main Authors Yoon, Nara, Lim, Sharon, Kang, So Young, Kwon, Ghee Young, Jeon, Hwang Gyun, Jeong, Byong Chang, Seo, Seong Il, Jeon, Seong Soo, Lee, Hyun Moo, Choi, Han Yong
Format Journal Article
LanguageEnglish
Published China Medknow Publications and Media Pvt. Ltd 01.05.2017
Medknow Publications & Media Pvt. Ltd
Medknow Publications & Media Pvt Ltd
Wolters Kluwer Medknow Publications
Subjects
Adenocarcinoma - epidemiology
Adenocarcinoma - genetics
Adult
Asian Continental Ancestry Group
Cancer surgery
Cohort Studies
Demography
Deoxyribonucleic acid
DNA
DNA, Neoplasm - genetics
Exons - genetics
Gene Frequency
Gene mutation
Genes
Genetic aspects
Genomics
Humans
Limit of Detection
Male
Mediator Complex - genetics
mediator complex subunit 12; mutation analysis; prostate cancer; prostate neoplasms
Mutation
Neoplasm Grading
Original
Pathology
Physiological aspects
Prostate cancer
Prostatectomy
Prostatic Neoplasms - epidemiology
Prostatic Neoplasms - genetics
Republic of Korea - epidemiology
Risk factors
Thermal cycling
Tumors
South Korea
United States > US
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Summary:Prostate cancer is one of the major health care problems, but the molecular pathogenesis has been relatively insufficiently elucidated. Recently, whole exome sequencing of prostate cancer identified recurrent mutations involving MED12 in Caucasian patients, which finding was not reproduced in one subsequent study by Sanger sequencing. Thus, we investigated mutation status of MED12 in exons 2 and 26 by Sanger sequencing in 102 radical prostatectomy cases from Korean patients. The analysis found the mutation in none of the cases. Therefore, MED12 mutation does not appear to represent a significant molecular alteration in this cohort of patients according to the analysis by the traditional ＂gold standard.＂
Bibliography:Prostate cancer is one of the major health care problems, but the molecular pathogenesis has been relatively insufficiently elucidated. Recently, whole exome sequencing of prostate cancer identified recurrent mutations involving MED12 in Caucasian patients, which finding was not reproduced in one subsequent study by Sanger sequencing. Thus, we investigated mutation status of MED12 in exons 2 and 26 by Sanger sequencing in 102 radical prostatectomy cases from Korean patients. The analysis found the mutation in none of the cases. Therefore, MED12 mutation does not appear to represent a significant molecular alteration in this cohort of patients according to the analysis by the traditional ＂gold standard.
mediator complex subunit 12; mutation analysis; prostate cancer; prostate neoplasms
31-1795/R
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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These authors contributed equally to this work.
ISSN:1008-682X
1745-7262
DOI:10.4103/1008-682X.172826