DiGAlign: Versatile and Interactive Visualization of Sequence Alignment for Comparative Genomics

• Published in: Microbes and Environments Vol. 39; no. 1; p. ME23061
• Main Authors: Nishimura, Yosuke, Yamada, Kohei, Okazaki, Yusuke, Ogata, Hiroyuki
• Format: Journal Article
• Language: English
• Published: Japan Japanese Society of Microbial Ecology / Japanese Society of Soil Microbiology / Taiwan Society of Microbial Ecology / Japanese Society of Plant Microbe Interactions / Japanese Society for Extremophiles 2024
• Subjects: alignment visualization; bioinformatics tool; comparative genomics; Genome; Genomics; Sequence Alignment; Short Communication; Software; synteny map; User-Computer Interface; web server; synteny map; bioinformatics tool; comparative genomics; alignment visualization; web server
• ISSN: 1342-6311; 1347-4405
• DOI: 10.1264/jsme2.ME23061

With the explosion of available genomic information, comparative genomics has become a central approach to understanding microbial ecology and evolution. We developed DiGAlign (https://www.genome.jp/digalign/), a web server that provides versatile functionality for comparative genomics with an intuitive interface. It allows the user to perform the highly customizable visualization of a synteny map by simply uploading nucleotide sequences of interest, ranging from a specific region to the whole genome landscape of microorganisms and viruses. DiGAlign will serve a wide range of biological researchers, particularly experimental biologists, with multifaceted features that allow the rapid characterization of genomic sequences of interest and the generation of a publication-ready figure.