Targeted Nasal Vaccination Provides Antibody-Independent Protection Against Staphylococcus aureus

• Published in: The Journal of infectious diseases Vol. 209; no. 9; pp. 1479 - 1484
• Main Authors: Misstear, Karen, McNeela, Edel A., Murphy, Alison G., Geoghegan, Joan A., O'Keeffe, Kate M., Fox, John, Chan, Kin, Heuking, Simon, Collin, Nicolas, Foster, Timothy J., McLoughlin, Rachel M., Lavelle, Ed C.
• Format: Journal Article
• Language: English
• Published: Oxford Oxford University Press 01.05.2014
• Subjects: Administration, Intranasal; Animals; Antibodies; Antibodies, Neutralizing - blood; Antigens; BACTERIA; Bacterial Load - immunology; Bacterial vaccines; Bacteriology; Biological and medical sciences; Female; Fundamental and applied biological sciences. Psychology; Immunity, Cellular - drug effects; Immunity, Cellular - immunology; Immunoglobulin G - blood; Infections; Infectious diseases; Medical sciences; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Microbiology; Miscellaneous; Nanoparticles; Nanoparticles - administration & dosage; Ova; Staphylococcal Infections - immunology; Staphylococcal Infections - microbiology; Staphylococcal Infections - prevention & control; Staphylococcal vaccines; Staphylococcal Vaccines - administration & dosage; Staphylococcal Vaccines - chemistry; Staphylococcal Vaccines - immunology; Staphylococcus aureus; Staphylococcus aureus - immunology; T lymphocytes; Vaccination; nanoparticle; vaccine; adjuvant; cellular immunity; mucosal; Infection; Antibody; Vaccination; Bacteria; Micrococcales; Micrococcaceae; Staphylococcus aureus
• ISSN: 0022-1899; 1537-6613
• DOI: 10.1093/infdis/jit636

Despite showing promise in preclinical models, anti-Staphylococcus aureus vaccines have failed in clinical trials. To date, approaches have focused on neutralizing/opsonizing antibodies; however, vaccines exclusively inducing cellular immunity have not been studied to formally test whether a cellular-only response can protect against infection. We demonstrate that nasal vaccination with targeted nanoparticles loaded with Staphylococcus aureus antigen protects against acute systemic S. aureus infection in the absence of any antigen-specific antibodies. These findings can help inform future developments in staphylococcal vaccine development and studies into the requirements for protective immunity against S. aureus.