Downregulation of MicroRNA-455-3p Links to Proliferation and Drug Resistance of Pancreatic Cancer Cells via Targeting TAZ

• Published in: Molecular therapy. Nucleic acids Vol. 10; pp. 215 - 226
• Main Authors: Zhan, Ting, Huang, Xiaodong, Tian, Xia, Chen, Xiaoli, Ding, Yu, Luo, Hesheng, Zhang, Yadong
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 02.03.2018; Elsevier Limited; American Society of Gene & Cell Therapy; Elsevier
• Subjects: Apoptosis; Cell growth; Cell proliferation; Chemoresistance; Chemotherapy; Drug resistance; Gemcitabine; Gene expression; Laboratory animals; Metastasis; MicroRNAs; miR-455-3p; miRNA; Ovarian cancer; Pancreatic cancer; TAZ; Tumor cell lines; Tumors; Beijing China; United States > US; China; miR-455-3p; pancreatic cancer; gemcitabine; drug resistance; TAZ
• ISSN: 2162-2531; 2162-2531
• DOI: 10.1016/j.omtn.2017.12.002

Drug resistance is a major cause of treatment failure in pancreatic cancer. The limited evidence indicates the involvement of miR-455-3p in chemotherapy resistance of cancer. Here we observed by qPCR that miR-455-3p was significantly decreased in pancreatic cancer tissues and cell lines. We then confirmed that the inhibition of miR-455-3p increased cell proliferation and gemcitabine resistance of pancreatic cancer, whereas forced overexpression of miR-455-3p had the opposite effect. Furthermore, we demonstrated that TAZ, which is associated with drug resistance of pancreatic cancer, is a new direct downstream target of miR-455-3p. Our present study suggests that miR-455-3p contributes to cell proliferation and drug resistance in pancreatic cancer cells via targeting TAZ.