神经肽Y促进肥胖的研究进展

神经肽Y（neuropeptide Y,NPY）是重要的促肥胖因子,广泛分布于中枢和外围神经系统,因此成为研发减肥药物的重要靶点。既往研究主要集中于NPY的中枢促摄食作用,但越来越多的证据表明NPY对能量代谢的调节是从多方面进行的。中枢和外围NPY均能通过促进棕色脂肪组织（brown adipose tissue,BAT）堆积而导致肥胖,本文主要从中枢和外周两方面对NPY的分布及其在肥胖发生发展过程中的作用进行综述。...

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Bibliographic Details
Published in复旦学报（医学版） Vol. 41; no. 6; pp. 850 - 854
Main Author 万云 李益明
Format Journal Article
LanguageChinese
Published 复旦大学附属华山医院内分泌科 上海200040 2014
Subjects
摄食
神经肽Y（NPY）
肥胖
能量代谢
肥胖
摄食
neuropeptide Y (NPY)
神经肽Y(NPY)
能量代谢
obesity
energy metabolism
food intake
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Summary:神经肽Y（neuropeptide Y,NPY）是重要的促肥胖因子,广泛分布于中枢和外围神经系统,因此成为研发减肥药物的重要靶点。既往研究主要集中于NPY的中枢促摄食作用,但越来越多的证据表明NPY对能量代谢的调节是从多方面进行的。中枢和外围NPY均能通过促进棕色脂肪组织（brown adipose tissue,BAT）堆积而导致肥胖,本文主要从中枢和外周两方面对NPY的分布及其在肥胖发生发展过程中的作用进行综述。
Bibliography:Neuropeptide Y （neuropeptide Y,NPY） is an important factor that promotes obesity that widely distributes in central and perpheral nervous system, thus making it a target for the development of drugs to lose weight. Although most researches have been focusing on its role in stimulating appetite,more and more evidence demonstrated that NPY regulates energy metabolism in many ways. Central and peripheral NPY can promote the storage of brown adipose tissue （BAT）, which finally lead to obesity. This review summarizes distributions of NPY and its role in the development of ohesily both centrally and peripherally.
neuropeptide Y （NPY） ; food intake；obesity; energy metabolism
WAN Yun, LI Yi-ming （ Department of Endocrinoloy and Metabolism, Huashan Hospital, Fudan University, Shanghai 210040,China）
31-1885/R
ISSN:1672-8467
DOI:10.3969/j.issn.1672-8467.2014.06.025