鼻咽部肿瘤体积在中国西北非高发区鼻咽癌患者中的预后价值

目的 探索鼻咽部肿瘤体积在中国西北非高发区鼻咽癌患者中的预后价值。方法 将2004-2011年接受根治性放疗的393例鼻咽癌患者纳入本研究,所有患者均通过鼻咽部组织活检明确为鼻咽癌,观察总生存率和无远处转移生存率,采用ROC曲线确定肿瘤体积最佳界值,Kaplan-Meier比较患者生存差异,COX比例风险回归模型探索独立预后因素。结果 患者5年总生存率和无远处转移生存率分别为74.3%和73.5%。根据肿瘤体积最佳界值将患者分为≤23mL组和〉23mL组,≤23mL组患者5年总生存率和无远处转移生存率明显高于〉23mL组,差异有统计学意义（P〈0.05）。多因素分析显示病理类型为分化亚型、肿瘤...

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Published in西安交通大学学报（医学版） Vol. 38; no. 1; pp. 117 - 121
Main Author 臧健 许曼 赵丽娜 石梅
Format Journal Article
LanguageChinese
Published 第四军医大学第一附属医院放射治疗科,陕西西安,710003 2017
Subjects
肿瘤体积
非高发区
预后
鼻咽癌
nasopharyngeal carcinoma
tumor volume
预后
鼻咽癌
肿瘤体积
非高发区
prognosis
non-endemic area
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Summary:目的 探索鼻咽部肿瘤体积在中国西北非高发区鼻咽癌患者中的预后价值。方法 将2004-2011年接受根治性放疗的393例鼻咽癌患者纳入本研究,所有患者均通过鼻咽部组织活检明确为鼻咽癌,观察总生存率和无远处转移生存率,采用ROC曲线确定肿瘤体积最佳界值,Kaplan-Meier比较患者生存差异,COX比例风险回归模型探索独立预后因素。结果 患者5年总生存率和无远处转移生存率分别为74.3%和73.5%。根据肿瘤体积最佳界值将患者分为≤23mL组和〉23mL组,≤23mL组患者5年总生存率和无远处转移生存率明显高于〉23mL组,差异有统计学意义（P〈0.05）。多因素分析显示病理类型为分化亚型、肿瘤体积〉23mL、N2~3为影响患者总生存率和无远处转移生存率的独立预后因素。结论 鼻咽部肿瘤体积是影响中国西北非高发区鼻咽癌患者生存的独立预后因素。
Bibliography:ZANG Jian, XU Man, ZHAO Li-na, SHI Mei （Department of Radiation Oncology, the First Affiliate Hospital of the Fourth Military Medical University, Xi＇an 710003, China）
nasopharyngeal carcinoma; tumor volume; non-endemic area; prognosis
Objective To investigate the prognostic value of primary tumor volume in non-endemic patients with nasopharynx carcinoma in northwest China. Methods A total of 393 patients were enrolled in the study and all the patients had been identified with nasopharynx squamous cell carcinoma by biopsy. Overall survival （OS） and distant metastasis free survival （DMFS） were the primary endpoints. The cut-off of tumor volume was identified by ROC curves. Survival results were analyzed by the Kaplan-Meier curve. Independent prognostic factors were identified by COX proportional hazards regression model. Results The 5-year OS and DMFS for all the patients were 74.3% and 73.5%. 23 mL was considered as the optimal cut-off value according to the ROC curves, and then the patients were divided into tw
ISSN:1671-8259
DOI:10.7652/jdyxb201701025