Functional Integration of Adult-Born Neurons

Over the past decade, it has become clear that neural stem cells in the adult mammalian brain continuously generate new neurons, predominantly in the hippocampus and olfactory bulb [1]. However, the central issue of whether these new neurons participate in functional synaptic circuitry has yet to be...

Full description

Saved in:
Bibliographic Details
Published inCurrent biology Vol. 12; no. 7; pp. 606 - 608
Main Authors Carlén, Marie, Cassidy, Robert M., Brismar, Hjalmar, Smith, Gregory A., Enquist, Lynn W., Frisén, Jonas
Format Journal Article
LanguageEnglish
Published England Elsevier Inc 02.04.2002
Subjects
Animals
Biomarkers
brain
Cell Differentiation
Cholera Toxin - metabolism
Dentate Gyrus - cytology
generated neurons
Herpesvirus 1, Suid - physiology
Hippocampus - cytology
Medicin och hälsovetenskap
Mice
Mice, Inbred C57BL
Neurons - cytology
Neurons - metabolism
Neurons - physiology
Neurons - virology
Olfactory Bulb - cytology
Olfactory Bulb - physiology
Proto-Oncogene Proteins c-fos - biosynthesis
Stem Cells - cytology
Stem Cells - metabolism
Stem Cells - physiology
Stem Cells - virology
Synapses - metabolism
Synapses - virology
Online AccessGet full text

Cover

More Information
Summary:Over the past decade, it has become clear that neural stem cells in the adult mammalian brain continuously generate new neurons, predominantly in the hippocampus and olfactory bulb [1]. However, the central issue of whether these new neurons participate in functional synaptic circuitry has yet to be resolved. Here, we use virus-based transsynaptic neuronal tracing and c-Fos mapping of odor-induced neuronal activity to demonstrate that neurons generated in the adult functionally integrate into the synaptic circuitry of the brain.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ISSN:0960-9822
1879-0445
1879-0445
DOI:10.1016/S0960-9822(02)00771-6