Tissue factor: an enzyme cofactor and a true receptor

• Published in: Thrombosis and haemostasis Vol. 86; no. 1; p. 66
• Main Author: Morrissey, J H
• Format: Journal Article
• Language: English
• Published: Germany 01.07.2001
• Subjects: Blood Coagulation - drug effects; Factor VIIa - chemistry; Factor VIIa - metabolism; Factor VIIa - physiology; Humans; Protein Binding; Protein Conformation; Thrombophilia - etiology; Thromboplastin - chemistry; Thromboplastin - metabolism; Thromboplastin - physiology

Tissue factor is considered to be the physiologic trigger of the blood clotting system in normal hemostasis and in many--perhaps most--thrombotic diseases. A wealth of new knowledge is available regarding the structure and assembly of the TF:VIIa complex and the role of factor VIIa and tissue factor...