Tissue factor: an enzyme cofactor and a true receptor

Tissue factor is considered to be the physiologic trigger of the blood clotting system in normal hemostasis and in many--perhaps most--thrombotic diseases. A wealth of new knowledge is available regarding the structure and assembly of the TF:VIIa complex and the role of factor VIIa and tissue factor...

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Bibliographic Details
Published inThrombosis and haemostasis Vol. 86; no. 1; p. 66
Main Author Morrissey, J H
Format Journal Article
LanguageEnglish
Published Germany 01.07.2001
Subjects
Blood Coagulation - drug effects
Factor VIIa - chemistry
Factor VIIa - metabolism
Factor VIIa - physiology
Humans
Protein Binding
Protein Conformation
Thrombophilia - etiology
Thromboplastin - chemistry
Thromboplastin - metabolism
Thromboplastin - physiology
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Summary:Tissue factor is considered to be the physiologic trigger of the blood clotting system in normal hemostasis and in many--perhaps most--thrombotic diseases. A wealth of new knowledge is available regarding the structure and assembly of the TF:VIIa complex and the role of factor VIIa and tissue factor in hypercoagulable states. The exciting recent finding that tissue factor can function as a signaling receptor, and suggestions that tissue factor may have important, non-hemostatic roles, will be the subject of much additional study in the near future.
ISSN:0340-6245
DOI:10.1055/s-0037-1616202