Mitochondria Initiate and Regulate Sarcopenia

We present the hypothesis that an accumulation of dysfunctional mitochondria initiates a signaling cascade leading to motor neuron and muscle fiber death and culminating in sarcopenia. Interactions between neural and muscle cells that contain dysfunctional mitochondria exacerbate sarcopenia. Prevent...

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Bibliographic Details
Published inExercise and sport sciences reviews Vol. 45; no. 2; p. 58
Main Authors Alway, Stephen E, Mohamed, Junaith S, Myers, Matthew J
Format Journal Article
LanguageEnglish
Published United States 01.04.2017
Subjects
Aging - metabolism
Animals
Apoptosis - physiology
Cell Death
Forkhead Box Protein O1 - metabolism
Humans
Mitochondria, Muscle - metabolism
Mitophagy
Motor Neurons - metabolism
Muscle, Skeletal - innervation
Muscle, Skeletal - metabolism
Muscular Atrophy - metabolism
Sarcopenia - metabolism
Signal Transduction
Ubiquitin - metabolism
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Summary:We present the hypothesis that an accumulation of dysfunctional mitochondria initiates a signaling cascade leading to motor neuron and muscle fiber death and culminating in sarcopenia. Interactions between neural and muscle cells that contain dysfunctional mitochondria exacerbate sarcopenia. Preventing sarcopenia will require identifying mitochondrial sources of dysfunction that are reversible.
ISSN:1538-3008
DOI:10.1249/JES.0000000000000101