Mechanisms of fat‐induced gastric inhibitory polypeptide/glucose‐dependent insulinotropic polypeptide secretion from K cells

• Published in: Journal of diabetes investigation Vol. 7; no. S1; pp. 20 - 26
• Main Authors: Yamane, Shunsuke, Harada, Norio, Inagaki, Nobuya
• Format: Journal Article
• Language: English
• Published: Japan John Wiley & Sons, Inc 01.04.2016; John Wiley and Sons Inc
• Subjects: Animals; Body mass index; Cell Line; Diabetes; Diet; Diet, High-Fat; Dietary Fats - administration & dosage; Dietary Fats - metabolism; DNA microarrays; Enteroendocrine Cells - secretion; Fatty Acid-Binding Proteins - metabolism; Fatty acids; Fatty acid‐binding protein 5; Gastric Inhibitory Polypeptide - genetics; Gastric Inhibitory Polypeptide - secretion; Gene expression; GIP gene; Glucose; Green fluorescent protein; G protein‐coupled receptor 120; High fat diet; Human subjects; Insulin; Insulin resistance; Insulin secretion; Menopause; Mice; Mice, Knockout; Mini Review; Neoplasm Proteins - metabolism; Obesity; Obesity - metabolism; Oral administration; Polypeptides; Protein arrays; Proteins; Receptors, G-Protein-Coupled - metabolism; Regulatory Factor X Transcription Factors - metabolism; Regulatory factor X6; Secretion; Small intestine; Japan; Regulatory factor X6; Fatty acid‐binding protein 5; G protein‐coupled receptor 120

Gastric inhibitory polypeptide/glucose‐dependent insulinotropic polypeptide (GIP) is one of the incretins, which are gastrointestinal hormones released in response to nutrient ingestion and potentiate glucose‐stimulated insulin secretion. Single fat ingestion stimulates GIP secretion from enteroendo...