Association between previously identified loci affecting telomere length and coronary heart disease (CHD) in Han Chinese population

• Published in: Clinical interventions in aging Vol. 9; pp. 857 - 861
• Main Authors: Ding, Hui, Yan, Fen, Zhou, Lin-Lin, Ji, Xiu-Hai, Gu, Xin-Nan, Tang, Zhi-Wei, Chen, Ru-Hua
• Format: Journal Article
• Language: English
• Published: New Zealand Dove Medical Press Limited 01.01.2014; Taylor & Francis Ltd; Dove Press; Dove Medical Press
• Subjects: Age; Age of Onset; Aging; Alleles; Apolipoproteins; Asian Continental Ancestry Group - genetics; Body mass index; Cardiovascular disease; Case-Control Studies; China - epidemiology; Cholesterol; Coronary Disease - etiology; Coronary Disease - genetics; Coronary heart disease; Coronary vessels; Deoxyribonucleic acid; Diabetes; DNA; Female; gene; Genetic aspects; Genetic Loci - genetics; Genome-Wide Association Study; Genotype; Genotype & phenotype; Han (Chinese people); Health aspects; Health risk assessment; Heart; Hospitals; Humans; Hypertension; Hypotheses; Identification and classification; leucocyte telomere length; Low density lipoprotein; Male; Medical imaging; Middle Aged; Original Research; Oxidative stress; Polymorphism, Single Nucleotide - genetics; Quantitative trait loci; Ribonucleoproteins - genetics; Risk factors; Senescence; Standard deviation; Statistical analysis; Systematic review; Telomere Homeostasis - genetics; Trends; Variance analysis; China; United States > US; gene; coronary heart disease; leucocyte telomere length
• ISSN: 1178-1998; 1176-9092; 1178-1998
• DOI: 10.2147/CIA.S60760

To replicate previously confirmed telomere-length loci in a Chinese Han population with coronary heart disease (CHD), and investigate these loci and the possibility of and age at onset of CHD. 1514 CHD patients and 2470 normal controls were recruited. Medical data including age, sex, body mass index, lipid profiles, history of hypertension, type 2 diabetes mellitus, and dyslipidemia were collected from all the participants. Seven previously identified single-nucleotide polymorphisms (SNPs) related to leucocyte telomere length were genotyped, including rs10936599 in TERC, rs2736100 in TERT, rs7675998 in NAF1, rs9420907 in OBFC1, rs8105767 in ZNF208, rs755017 in RTEL1, and rs11125529 in ACYP2. No significant difference in genotype frequencies from the Hardy-Weinberg equilibrium test was noted for all tested SNPs both in the CHD patients and the normal controls. No polymorphism was observed for rs9420907, and AA genotype was noted in both the CHD patients and the controls. Neither the genotype nor the allele frequencies of rs2736100, rs8105767, rs11125529, and rs2967374 were significantly different between the CHD patients and the normal controls. For rs10936599 and rs755017, statistical difference was found for the allele frequency but not genotype. Distributions of genotype and allele were significantly different between the two groups for rs7675998. The odds ratio for carriers of CHD was 2.127 (95% confidence interval: 1.909-2.370) for the A allele of rs7675998. By one-way analysis of variance test, rs7675998 was associated with the onset age of CHD. CHD patients with the AA genotype of rs7675998 had significantly lower onset age (P<0.05). In a Chinese Han population, NAF1 gene encoding proteins with known function in telomere biology may influence both the possibility of and the age at onset of CHD, as previously reported in European studies.