Left Ventricular Dyssynchrony Acutely After Myocardial Infarction Predicts Left Ventricular Remodeling

• Published in: Journal of the American College of Cardiology Vol. 50; no. 16; pp. 1532 - 1540
• Main Authors: Mollema, Sjoerd A., MD, Liem, Su San, MD, Suffoletto, Matthew S., MD, Bleeker, Gabe B., MD, van der Hoeven, Bas L., MD, van de Veire, Nico R., MD, PhD, Boersma, Eric, PhD, Holman, Eduard R., MD, PhD, van der Wall, Ernst E., MD, PhD, Schalij, Martin J., MD, PhD, Gorcsan, John, MD, Bax, Jeroen J., MD, PhD
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 16.10.2007; Elsevier Science; Elsevier Limited
• Subjects: Angioplasty, Balloon, Coronary; Biological and medical sciences; Cardiology; Cardiology. Vascular system; Cardiovascular; Cardiovascular disease; Confidence intervals; Coronary heart disease; Coronary vessels; Creatine Kinase - blood; Female; Heart; Heart attacks; Humans; Hypertension; Image Processing, Computer-Assisted; Internal Medicine; Male; Medical sciences; Middle Aged; Mitral Valve Insufficiency - diagnostic imaging; Mitral Valve Insufficiency - physiopathology; Multivariate Analysis; Myocardial Infarction - physiopathology; Myocardial Infarction - therapy; Myocarditis. Cardiomyopathies; ROC Curve; Sensitivity and Specificity; Severity of Illness Index; Software; Stroke Volume - physiology; Troponin T - blood; Ultrasonography, Doppler, Color; Ultrasonography, Doppler, Pulsed; Ventricular Dysfunction, Left - diagnostic imaging; Ventricular Dysfunction, Left - physiopathology; Ventricular Remodeling - physiology; WMSI; LVEF; LVESV; LV; wall motion score index; left ventricular ejection fraction; left atrium/atrial; 2D; two-dimensional; left ventricular end-diastolic volume; LA; E/E; LVEDV; left ventricle/ventricular; mitral inflow peak early velocity/mitral annular peak early velocity; left ventricular end-systolic volume; Myocardial infarction; Vascular remodeling; Heart disease; Prediction; Cardiovascular disease; Circulatory system; Cardiology; Myocardial disease; Phlebology; Left ventricle
• ISSN: 0735-1097; 1558-3597
• DOI: 10.1016/j.jacc.2007.07.025

Left Ventricular Dyssynchrony Acutely After Myocardial Infarction Predicts Left Ventricular Remodeling Sjoerd A. Mollema, Su San Liem, Matthew S. Suffoletto, Gabe B. Bleeker, Bas L. van der Hoeven, Nico R. van de Veire, Eric Boersma, Eduard R. Holman, Ernst E. van der Wall, Martin J. Schalij, John Gorcsan III, Jeroen J. Bax This study was designed to predict left ventricular (LV) remodeling at 6-month follow-up after acute myocardial infarction. In total, 178 patients presented with acute myocardial infarction and underwent primary percutaneous coronary intervention. LV dyssynchrony, assessed at baseline by speckle-tracking radial strain analysis, was demonstrated to be superior in predicting LV remodeling at 6-month follow-up. Using a cutoff value of 130 ms, a sensitivity of 82% and a specificity of 95% were obtained to predict long-term LV remodeling.