Powering an Inorganic Nanodevice with a Biomolecular Motor

• Published in: Science (American Association for the Advancement of Science) Vol. 290; no. 5496; pp. 1555 - 1558
• Main Authors: Soong, Ricky K., Bachand, George D., Neves, Hercules P., Olkhovets, Anatoli G., Craighead, Harold G., Montemagno, Carlo D.
• Format: Journal Article
• Language: English
• Published: Washington, DC American Society for the Advancement of Science 24.11.2000; American Association for the Advancement of Science; The American Association for the Advancement of Science
• Subjects: Adenosine Triphosphate - metabolism; Aerospace Education; Analytical biochemistry: general aspects, technics, instrumentation; Analytical, structural and metabolic biochemistry; Angular velocity; Biochemistry; Bioengineering; Biological and medical sciences; Biotechnology - instrumentation; Biotechnology - methods; Biotinylation; Cylinders; Engineering; Enzyme Inhibitors; Fundamental and applied biological sciences. Psychology; Genetic engineering; Miniaturization; Molecular electronics; Molecular Motor Proteins; Molecules; Motors; Nanotechnology; Nickel - metabolism; Physics; Propellers; Proton-Translocating ATPases - antagonists & inhibitors; Proton-Translocating ATPases - metabolism; Recombinant Proteins; Research fellowships; Rotation; Sodium Azide - pharmacology; Torque; Enzyme; Myosin; Contractile protein; H; Hydrolases; Biology; transporting ATP synthase; Engine; Nanotechnology
• ISSN: 0036-8075; 1095-9203
• DOI: 10.1126/science.290.5496.1555

Biomolecular motors such as F1-adenosine triphosphate synthase (F1-ATPase) and myosin are similar in size, and they generate forces compatible with currently producible nanoengineered structures. We have engineered individual biomolecular motors and nanoscale inorganic systems, and we describe their integration in a hybrid nanomechanical device powered by a biomolecular motor. The device consisted of three components: an engineered substrate, an F1-ATPase biomolecular motor, and fabricated nanopropellers. Rotation of the nanopropeller was initiated with 2 mM adenosine triphosphate and inhibited by sodium azide.