Stress Cardiomyopathy After Intravenous Administration of Catecholamines and Beta-Receptor Agonists

• Published in: Journal of the American College of Cardiology Vol. 53; no. 15; pp. 1320 - 1325
• Main Authors: Abraham, Jacob, MD, Mudd, James O., MD, Kapur, Navin, MD, Klein, Kelly, Champion, Hunter C., MD, PhD, Wittstein, Ilan S., MD
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 14.04.2009; Elsevier; Elsevier Limited
• Subjects: Adrenergic beta-Agonists - administration & dosage; Adrenergic beta-Agonists - adverse effects; Adult; beta-receptor agonists; Biological and medical sciences; Cardiology; Cardiology. Vascular system; Cardiomyopathies - chemically induced; Cardiomyopathy; Cardiovascular; Cardiovascular Agents - administration & dosage; Cardiovascular Agents - adverse effects; Cardiovascular disease; catecholamines; Catecholamines - administration & dosage; Catecholamines - adverse effects; Coronary vessels; Dobutamine - administration & dosage; Dobutamine - adverse effects; Dopamine; Drug dosages; Electrocardiography; Epinephrine - administration & dosage; Epinephrine - adverse effects; Female; Heart; Heart attacks; Heart rate; Humans; Infusions, Intravenous; Internal Medicine; Intubation; Male; Medical imaging; Medical sciences; Middle Aged; Pain; Patients; Signal transduction; stress cardiomyopathy; Suicides & suicide attempts; ventricular ballooning; Ventricular Dysfunction, Left - chemically induced; intra-aortic balloon pump; catecholamines; corrected QT interval; stress cardiomyopathy; IABP; ECG; LV; IQR; interquartile range; beta-receptor agonists; ventricular ballooning; QTc interval; left ventricle/ventricular; SCM; electrocardiogram/electrocardiographic; Intravenous administration; Cardiovascular disease; β-Adrenergic receptor agonist; Circulatory system; Stress cardiomyopathy; Cardiology; Catecholamine; Biological receptor
• ISSN: 0735-1097; 1558-3597
• DOI: 10.1016/j.jacc.2009.02.020

Objectives The aim of this study was to report a series of patients with stress cardiomyopathy precipitated by the intravenous administration of catecholamines and beta-receptor agonists. Background Stress cardiomyopathy is a syndrome of transient cardiac dysfunction precipitated by intense emotional or physical stress. Excessive sympathetic stimulation is believed to be central to the pathogenesis of this disorder, but a causal link has not been convincingly demonstrated. Methods We observed 9 cases of stress cardiomyopathy precipitated immediately by the intravenous administration of epinephrine (n = 6) or dobutamine (n = 3). Patients were evaluated with coronary angiography and with serial echocardiography, electrocardiography, and cardiac enzymes. Results The median age was 44 years (interquartile range [IQR]: 30 to 48 years), and 7 (78%) were woman. Troponin-I was mildly elevated (median 4.07 ng/ml, IQR: 0.47 to 5.63 ng/ml), but none of the patients undergoing angiography had obstructive coronary disease. All patients developed corrected QT interval (QTc interval) prolongation (median QTc interval 504 ms, IQR: 477 to 568 ms) within 24 h of receiving drug. All 3 previously described variants of left ventricular “ballooning” (apical, midventricular, and basal) were observed. The median ejection fraction on admission was 35% (IQR: 35% to 40%). During follow-up (median 7 days, IQR: 4 to 13 days) there was recovery of left ventricular systolic function in all patients (median ejection fraction 55%, IQR: 40% to 60%, p < 0.001 vs. admission). Conclusions Exposure to catecholamines and beta-receptor agonists used routinely during procedures and diagnostic tests can precipitate all the features of stress cardiomyopathy, including cardiac isoenzyme elevation, QTc interval prolongation, and rapidly reversible cardiac dysfunction. These observations strongly implicate excessive sympathetic stimulation as central to the pathogenesis of this unique syndrome.