Outcome and Growth Potential of Left Heart Structures After Neonatal Intervention for Aortic Valve Stenosis

• Published in: Journal of the American College of Cardiology Vol. 50; no. 25; pp. 2406 - 2414
• Main Authors: Han, Ra K., MD, FRCPC, Gurofsky, Rebecca C., BSc, Lee, Kyong-Jin, MD, FRCPC, Dipchand, Anne I., MD, FRCPC, Williams, William G., MD, FRCSC, Smallhorn, Jeffrey F., MD, FRCPC, McCrindle, Brian W., MD, MPH, FRCPC
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 18.12.2007; Elsevier Science; Elsevier Limited
• Subjects: Age; Angiography; Aortic Valve - physiopathology; Aortic Valve Stenosis - congenital; Aortic Valve Stenosis - mortality; Aortic Valve Stenosis - physiopathology; Aortic Valve Stenosis - therapy; Biological and medical sciences; Cardiac Volume - physiology; Cardiology; Cardiology. Vascular system; Cardiovascular; Catheterization; Cause of Death; Child; Child, Preschool; Coronary vessels; Data analysis; Echocardiography; Endocardial and cardiac valvular diseases; Female; Heart; Heart Valve Prosthesis Implantation; Heart Ventricles - physiopathology; Hemodynamics - physiology; Humans; Hypoplastic Left Heart Syndrome - mortality; Hypoplastic Left Heart Syndrome - physiopathology; Hypoplastic Left Heart Syndrome - therapy; Infant; Infant, Newborn; Internal Medicine; Intervention; Longitudinal Studies; Male; Medical sciences; Mitral Valve - abnormalities; Mitral Valve - physiopathology; Mortality; Multivariate Analysis; Patients; Risk Factors; Sinuses; Studies; Survival Rate; Ultrasonic imaging; Ventricular Dysfunction, Left - mortality; Ventricular Dysfunction, Left - physiopathology; Ventricular Dysfunction, Left - therapy; parameter estimates; left ventricular end-diastolic; PE; CI; CHSS; confidence interval; LV; LVED; left ventricle/ventricular; Congenital Heart Surgeons Society; Human; Aortic stenosis; Neonatal; Prognosis; Growth; Cardiovascular disease; Potential; Left heart; Newborn; Cardiac valvular disease; Evolution; Circulatory system; Cardiology; Structure; Aortic valve
• ISSN: 0735-1097; 1558-3597
• DOI: 10.1016/j.jacc.2007.07.082

Outcome and Growth Potential of Left Heart Structures After Neonatal Intervention for Aortic Valve Stenosis Ra K. Han, Rebecca C. Gurofsky, Kyong-Jin Lee, Anne I. Dipchand, William G. Williams, Jeffrey F. Smallhorn, Brian W. McCrindle We studied 53 patients who underwent neonatal balloon aortic valve dilation to determine trends in longitudinal changes in left heart dimensions. Aortic valve annulus, aortic sinus, and left ventricular (LV) dimension z -scores were initially below normal but increased over time, whereas mitral valve z -scores remained below normal. Initial z -scores and growth of other left heart structures were independent predictors of growth. Hence, there is potential catch-up growth of the aortic valve and LV over time, although the continued hypoplasia of the mitral valve warrants further consideration in the long-term management of these patients.