Multiple Attack on Bacteria by the New Antibiotic Teixobactin

News from the antibiotics pipeline: The discovery of a depsipeptide‐type lipid II binder, isolated from a previously unknown bacterium, raises hopes in the battle against multiresistant staphylococci.

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Bibliographic Details
Published inAngewandte Chemie (International ed.) Vol. 54; no. 23; pp. 6684 - 6686
Main Authors von Nussbaum, Franz, Süssmuth, Roderich D
Format Journal Article
LanguageEnglish
Published Weinheim WILEY-VCH Verlag 01.06.2015
WILEY‐VCH Verlag
Wiley Subscription Services, Inc
EditionInternational ed. in English
Subjects
Anti-Bacterial Agents - chemistry
Anti-Bacterial Agents - pharmacology
Antibiotics
Bacteria
Bacteria - drug effects
Binders
cell-wall biosynthesis
depsipeptides
Depsipeptides - chemistry
Depsipeptides - pharmacology
lipid II
Microbial Sensitivity Tests
Molecular Conformation
News
nonproteinogenic amino acids
Pipelines
depsipeptides
cell-wall biosynthesis
nonproteinogenic amino acids
antibiotics
lipid II
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Summary:News from the antibiotics pipeline: The discovery of a depsipeptide‐type lipid II binder, isolated from a previously unknown bacterium, raises hopes in the battle against multiresistant staphylococci.
Bibliography:Deutsche Forschungsgemeinschaft (DFG)
ark:/67375/WNG-GDWQ5DP9-H
We thank Dr. John Weston (Frankfurt), Dr. Todor Baramov (TU Berlin), and Dr. Guido Schiffer (Bayer HealthCare) for stimulating discussions. The work was supported by the cluster of excellence "UniCat" ("unifying concepts in catalysis"), which is funded by the Deutsche Forschungsgemeinschaft (DFG).
istex:9A07D80BF6B85354DED2EBE652A4D36B2E6ED756
ArticleID:ANIE201501440
We thank Dr. John Weston (Frankfurt), Dr. Todor Baramov (TU Berlin), and Dr. Guido Schiffer (Bayer HealthCare) for stimulating discussions. The work was supported by the cluster of excellence “UniCat” (“unifying concepts in catalysis”), which is funded by the Deutsche Forschungsgemeinschaft (DFG).
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201501440