Chronic dietary exposure to inorganic arsenic

• Published in: EFSA journal Vol. 19; no. 1; pp. e06380 - n/a
• Main Authors: Arcella, Davide, Cascio, Claudia, Gómez Ruiz, Jose Ángel
• Format: Journal Article
• Language: English
• Published: United States John Wiley & Sons, Inc 01.01.2021; John Wiley and Sons Inc; Wiley
• Subjects: Acids; Arsenic; Body weight; Carcinogens; Confidence limits; Contaminants; Diet; dietary exposure assessment; Drinking water; Estimates; Exposure; Food chains; Food contamination; Food groups; Grain; Infants; inorganic arsenic; Lower bounds; Lung cancer; Population; Rice; rice‐based commodities; Scientific Report; Skin; Toddlers; Upper bounds; inorganic arsenic; rice‐based commodities; drinking water; rice; dietary exposure assessment
• ISSN: 1831-4732; 1831-4732; 2314-9396
• DOI: 10.2903/j.efsa.2021.6380

Following an official request to EFSA from the European Commission, EFSA assessed the chronic dietary exposure to inorganic arsenic (iAs) in the European population. A total of 13,608 analytical results on iAs were considered in the current assessment (7,623 corresponding to drinking water and 5,985 to different types of food). Samples were collected across Europe between 2013 and 2018. The highest mean dietary exposure estimates at the lower bound (LB) were in toddlers (0.30 μg/kg body weight (bw) per day), and in both infants and toddlers (0.61 μg/kg bw per day) at the upper bound (UB). At the 95th percentile, the highest exposure estimates (LB–UB) were 0.58 and 1.20 μg/kg bw per day in toddlers and infants, respectively. In general, UB estimates were two to three times higher than LB estimates. The mean dietary exposure estimates (LB) were overall below the range of benchmark dose lower confidence limit (BMDL01) values of 0.3–8 μg/kg bw per day established by the EFSA Panel on Contaminants in the Food Chain in 2009. However, for the 95th percentile dietary exposure (LB), the maximum estimates for infants, toddlers and other children were within this range of BMDL01 values. Across the different age classes, the main contributors to the dietary exposure to iAs (LB) were ‘Rice’, ‘Rice‐based products’, ‘Grains and grain‐based products (no rice)’ and ‘Drinking water’. Different ad hoc exposure scenarios (e.g. consumption of rice‐based formulae) showed dietary exposure estimates in average and for high consumers close to or within the range of BMDL01 values. The main uncertainties associated with the dietary exposure estimations refer to the impact of using the substitution method to treat the left‐censored data (LB–UB differences), to the lack of information (consumption and occurrence) on some iAs‐containing ingredients in specific food groups, and to the effect of food preparation on the iAs levels. Recommendations were addressed to improve future dietary exposure assessments to iAs.