Identification and quantification of 4-methylethcathinone (4-MEC) and 3,4-methylenedioxypyrovalerone (MDPV) in hair by LC-MS/MS after chronic administration

Highlights • First method allowing simultaneously measurement of 4-MEC and MDPV in hair. • Very sensitive method with LLOQ set at 1 pg/mg for both compounds. • First 4-MEC result in hair in a chronic abuser of this compound.

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Bibliographic Details
Published inForensic science international Vol. 270; pp. 39 - 45
Main Authors Alvarez, Jean Claude, Etting, Isabelle, Abe, Emuri, Villa, Antoine, Fabresse, Nicolas
Format Journal Article
LanguageEnglish
Published Ireland Elsevier B.V 01.01.2017
Elsevier Limited
Subjects
3,4-Methylenedioxypyrovalerone
4-Methylethcathinone
Accuracy
Adult
Amphetamines
Amphetamines - analysis
Benzodioxoles - analysis
Cardiac arrhythmia
Chromatography
Chromatography, Liquid
Cocaine
Consumption
Designer drugs
Designer Drugs - analysis
Dopamine
Drugs
Elution
Forensic science
Forensic sciences
Forensic Toxicology - methods
Hair
Hair - chemistry
Humans
LC–MS–MS
Male
Mass Spectrometry
Methods
Pathology
Patients
Phosphates
Propiophenones - analysis
Psychotropic drugs
Pyrrolidines - analysis
Scientific imaging
Substance Abuse Detection
Substance-Related Disorders - diagnosis
Tachycardia
Urine
3,4-Methylenedioxypyrovalerone
hair
designer drugs
4-Methylethcathinone
LC-MS-MS
Hair
LC–MS–MS
Designer drugs
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Summary:Highlights • First method allowing simultaneously measurement of 4-MEC and MDPV in hair. • Very sensitive method with LLOQ set at 1 pg/mg for both compounds. • First 4-MEC result in hair in a chronic abuser of this compound.
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ISSN:0379-0738
1872-6283
DOI:10.1016/j.forsciint.2016.11.028